Publication Name	World Journal of Gastroenterology
Manuscript ID	121753
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	OH-CATH30 targets CD40 to suppress NF-κB signaling and promote arachidonic acid metabolic reprogramming in acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Ke-Liang Li, Yue Zhao, Wei-Jie Shang, Qi-Hang Guo, Hai-Tao Liu, Ji-Yu Zhang, Xue-Lin Jia and Bing-Rong Liu
Funding Agency and Grant Number	Funding Agency Grant Number Zhongyuan Talent Program ZYYCYU202012113 Key R&D Program of Henan Province 231111311600 Outstanding Foreign Scientist Studio Project of Henan Province GZS2020006
Corresponding Author	Bing-Rong Liu, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. fccliubr@zzu.edu.cn
Key Words	Acute pancreatitis; OH-CATH30; CD40; Nuclear factor-kappa B signaling; Macrophage polarization; Anti-inflammatory peptide; Arachidonic acid metabolism
Core Tip	This study identifies CD40 as a pivotal therapeutic target in acute pancreatitis. The antimicrobial peptide OH-CATH30 binds to CD40 and suppresses the CD40-tumor necrosis factor receptor-associated factor 6-transforming growth factor beta-activated kinase 1-nuclear factor-kappa B signaling cascade. This inhibition drives macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype and corrects arachidonic acid metabolic dysregulation. These findings establish CD40 as a central node that links inflammatory signaling and metabolic reprogramming in acute pancreatitis. Thus, OH-CATH30 is a promising multi-functional therapeutic candidate for this devastating inflammatory disease.
Citation	Li KL, Zhao Y, Shang WJ, Guo QH, Liu HT, Zhang JY, Jia XL, Liu BR. OH-CATH30 targets CD40 to suppress NF-κB signaling and promote arachidonic acid metabolic reprogramming in acute pancreatitis. World J Gastroenterol 2026; In press

Received	2026-04-01 03:44
Peer-Review Started	2026-04-01 03:45
First Decision by Editorial Office Director	2026-04-10 10:28
Return for Revision	2026-04-10 10:28
Revised	2026-04-25 06:07
Publication Fee Transferred	2026-04-29 04:05
Second Decision by Editor	2026-05-29 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-29 06:45
Articles in Press	2026-05-29 06:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com