Publication Name	World Journal of Clinical Oncology
Manuscript ID	121766
DOI	10.5306/wjco.121766
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Multidimensional mechanisms of drug resistance in non-small cell lung cancer and novel strategies for overcoming it
Manuscript Source	Invited Manuscript
All Author List	Xiang-Yi Zhang, Xin-Yu Pan, Yong Zhu, Min Hu, Shuo Ma, Si-Yan Zheng, Ci-Hang Wu, Yi-Luo Xie and Yi-Chi Xie
Funding Agency and Grant Number
Corresponding Author	Yi-Chi Xie, MD, Department of Emergency, Changzhou Geriatric Hospital Affiliated to Soochow University, No. 288 Yanling East Road, Changzhou 213000, Jiangsu Province, China. xieyichi2000@163.com
Key Words	Non-small lung cancer; Cancer; Drug; Multidimensional mechanisms; Novel strategies
Core Tip	Drug resistance in non-small cell lung cancer is not driven by single mechanisms but by a dynamic, multidimensional system shaped by clonal evolution, spatial heterogeneity, and tumor-immune interactions. This review advances a unified framework linking these dimensions and highlights how emerging strategies - including antibody-drug conjugates, bispecific antibodies, and targeted protein degradation - can overcome resistance. Integration of multi-omics and liquid biopsy is proposed as the foundation for adaptive, precision oncology.
Citation	Zhang XY, Pan XY, Zhu Y, Hu M, Ma S, Zheng SY, Wu CH, Xie YL, Xie YC. Multidimensional mechanisms of drug resistance in non-small cell lung cancer and novel strategies for overcoming it. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.121766

Received	2026-04-01 07:06
Peer-Review Started	2026-04-01 07:09
First Decision by Editorial Office Director	2026-04-22 10:59
Return for Revision	2026-04-22 10:59
Revised	2026-05-17 13:11
Publication Fee Transferred
Second Decision by Editor	2026-06-12 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-12 03:23
Articles in Press	2026-06-12 03:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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