Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	121769
DOI	10.4240/wjgs.121769
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Expression and efficacy of the long noncoding RNA Linc00909 in chemoradiotherapy of colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yong Wu, Yi-Yi Zhang, Bing-Jie Guan, Hua-Jun Cai and Guo-Xian Guan
Funding Agency and Grant Number	Funding Agency Grant Number Fujian Provincial Health Technology Project 2023QNA038 Joint Funds for the Innovation of Science and Technology, Fujian Province 2020Y9125 Fujian Province Finance Project BPB-2023GGX
Corresponding Author	Guo-Xian Guan, MD, Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. fjxhggx@163.com
Key Words	Colorectal cancer; Linc00909; Neoadjuvant chemoradiotherapy; Prognosis; Therapy resistance
Core Tip	Using 196 paired colorectal cancer and adjacent tissues from 30 patients with rectal cancer (19 resistant, 11 sensitive) to neoadjuvant chemoradiotherapy, we assessed Linc00909 expression via real-time polymerase chain reaction and correlated it with survival outcomes. Functional assays in Linc00909-overexpressing SW620 and DLD1 cells - including cholecystokinin-8, flow cytometry, and sphere formation - evaluated proliferation, cell cycle, apoptosis, stemness, and 5-FU/radiotherapy sensitivity. Tumorigenicity was examined in vivo. Bioinformatics and molecular experiments explored Linc00909’s ceRNA mechanism.
Citation	Wu Y, Zhang YY, Guan BJ, Cai HJ, Guan GX. Expression and efficacy of the long noncoding RNA Linc00909 in chemoradiotherapy of colorectal cancer. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.121769
PDF	121769-in-press.pdf

Received	2026-04-01 03:15
Peer-Review Started	2026-04-01 03:16
First Decision by Editorial Office Director
Return for Revision	2026-07-01 03:37
Revised	2026-08-06 13:46
Publication Fee Transferred	2026-09-16 13:34
Second Decision by Editor	2026-10-15 03:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-16 09:02
Articles in Press	2026-10-16 09:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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