Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121785
Country	China

Category	Anesthesiology
Manuscript Type	Randomized Controlled Trial
Article Title	Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Ting-Ting Ma, Jun Tong and Mei-Yu Liu
Funding Agency and Grant Number	Funding Agency Grant Number Chronic Disease Management Research Project of National Health Commission Capacity Building and Continuing Education Center No. CWJJMB202510042058
Corresponding Author	Ting-Ting Ma, Department of Anesthesiology, Yizheng Hospital, Nanjing Drum Tower Hospital Group, No. 1 Huan South Road, Yangzhou 211400, Jiangsu Province, China. 18225909566@163.com
Key Words	Hypertension; Gastrointestinal tumors; Surgery; Remimazolam; Myocardial injury after non-cardiac surgery; Cardioprotection
Core Tip	This randomized controlled study demonstrates that remimazolam-based anesthesia provides significant cardioprotective effects in elderly hypertensive patients undergoing gastrointestinal tumor surgery. Compared with conventional anesthesia, remimazolam reduces cardiac biomarker levels, improves hemodynamic stability, alleviates postoperative pain and agitation, and lowers the incidence of myocardial injury after non-cardiac surgery. These findings suggest that remimazolam may be a safer anesthetic option in high-risk elderly populations and highlight potential strategies for preventing perioperative cardiac complications.
Citation	Ma TT, Tong J, Liu MY. Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial. World J Gastrointest Oncol 2026; In press

Received	2026-04-14 09:17
Peer-Review Started	2026-04-14 09:18
First Decision by Editorial Office Director	2026-04-23 03:15
Return for Revision	2026-04-23 03:15
Revised	2026-05-07 13:07
Publication Fee Transferred	2026-05-10 13:55
Second Decision by Editor	2026-05-26 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-26 07:14
Articles in Press	2026-05-26 07:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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