Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	121798
DOI	10.4291/wjgp.121798
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Field of Vision
Article Title	Paradoxical nutrient hyperabsorption despite diarrhea: Insights from jejunal transcriptomic reanalysis in Linghu’s obesity-diarrhea syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Tong Niu, Xiang-Yao Wang and En-qiang Ling-Hu
Funding Agency and Grant Number
Corresponding Author	En-qiang Ling-Hu, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 94 Weijin Road, Beijing 100853, China. linghuenqiang@vip.sina.com
Key Words	Obesity; Chronic diarrhea; Hyperabsorption; Jejunum; Transcriptome
Core Tip	The jejunal mucosa of patients with Linghu’s obesity-diarrhea syndrome exhibits a unique state of “diarrhea-hyperabsorption”, involving fat digestion and absorption, carbohydrate uptake and transport, and protein catabolism. We hypothesize that this hyperabsorption state may be co-induced by physiological compensation, pathological drivers, and microbial dysbiosis. These findings provide a novel perspective for the clinical management of patients with obesity-diarrhea syndrome.
Citation	Niu XT, Wang XY, Linghu EQ. Paradoxical nutrient hyperabsorption despite diarrhea: Insights from jejunal transcriptomic reanalysis in Linghu’s obesity-diarrhea syndrome. World J Gastrointest Pathophysiol 2026; In press DOI: https://doi.org/10.4291/wjgp.121798
PDF	121798-in-press.pdf

Received	2026-04-02 00:36
Peer-Review Started	2026-04-02 00:38
First Decision by Editorial Office Director	2026-04-13 09:45
Return for Revision	2026-04-16 04:05
Revised	2026-05-06 14:05
Publication Fee Transferred
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 03:57
Articles in Press	2026-06-22 03:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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