Publication Name	World Journal of Gastroenterology
Manuscript ID	121805
DOI	10.3748/wjg.121805
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Advances on mechanisms and structural classification of Chinese herbal monomers against hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Lian Zheng, Pu-Zhao Chen, Tong Yu, Jie Zhang, Bing-Jiu Lu and Bao-Cheng Deng
Funding Agency and Grant Number	Funding Agency Grant Number The Sixth Batch of the National Clinical Excellence Training Program for Traditional Chinese Medicine Talents The Second Cohort of Liaoning Provincial Outstanding Talents in Traditional Chinese Medicine Program Science Planing Project of Liaoning Province No. 2025-BS-0727
Corresponding Author	Bing-Jiu Lu, Chief Physician, Department of Hepatology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110032, Liaoning Province, China. lubingjiu@163.com
Key Words	Hepatocellular carcinoma; Chinese herbal monomers; Flavonoids; Saponins; Apoptosis; Cell cycle arrest; Drug delivery systems; Ferroptosis; Immunomodulation
Core Tip	Hepatocellular carcinoma is a common and deadly liver cancer. This review focuses on active compounds from traditional Chinese herbs, organized by chemical structure. These natural compounds can suppress tumors in multiple ways simultaneously: They induce tumor cell death, block proliferation and metastasis, and modulate the immune microenvironment. By linking chemical structure to biological activity, this review provides a useful guide for developing these compounds into new liver cancer drugs, with an emphasis on recent advances in overcoming translational barriers such as poor bioavailability and lack of clinical evidence.
Citation	Zheng JL, Chen PZ, Yu T, Zhang J, Lu BJ, Deng BC. Advances on mechanisms and structural classification of Chinese herbal monomers against hepatocellular carcinoma. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121805
PDF	121805-in-press.pdf

Received	2026-04-02 01:26
Peer-Review Started	2026-04-02 01:27
First Decision by Editorial Office Director	2026-06-09 08:38
Return for Revision	2026-06-09 08:38
Revised	2026-06-22 05:13
Publication Fee Transferred	2026-07-03 03:54
Second Decision by Editor	2026-07-17 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-17 03:35
Articles in Press	2026-07-17 03:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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