Publication Name	World Journal of Transplantation
Manuscript ID	121821
DOI	10.5500/wjt.121821
Country	United Kingdom

Category	Transplantation
Manuscript Type	Observational Study
Article Title	Machine perfusion distribution across clinical phenotypes in kidney transplantation: A national cohort study using unsupervised clustering
Manuscript Source	Invited Manuscript
All Author List	Juanita Castellanos De Brigard, Ervandy Rangganata and Vassilios E Papalois
Funding Agency and Grant Number
Corresponding Author	Juanita Castellanos De Brigard, MD, Department of Surgery and Cancer, Imperial College London, South Kensington Campus, SW7 2AZ,, London W12 0HS, United Kingdom. j.castellanos-de-brigard24@imperial.ac.uk
Key Words	Kidney transplant; Hypothermic machine perfusion; Normothermic machine perfusion; Machine learning; Clustering; Phenotype
Core Tip	Using unsupervised clustering, we identified latent clinical phenotypes that demonstrated a non-random distribution of machine perfusion (MP) across the population. MP cases were notably concentrated within specific clusters, while the overall cluster structure remained mostly stable when focusing solely on MP recipients. This indicates that MP is integrated within the wider phenotypic landscape rather than creating distinct subgroups. Importantly, these phenotypes continued to hold outcome patterns within the MP cohort, although some varied among certain clusters. These findings suggest that MP interacts with the underlying profiles of recipients and donors, potentially altering outcome trajectories depending on the specific phenotype.
Citation	Castellanos De Brigard J, Rangganata E, Papalois VE. Machine perfusion distribution across clinical phenotypes in kidney transplantation: A national cohort study using unsupervised clustering. World J Transplant 2026; In press DOI: https://doi.org/10.5500/wjt.121821
PDF	121821-in-press.pdf

Received	2026-04-17 01:30
Peer-Review Started	2026-04-17 01:30
First Decision by Editorial Office Director	2026-06-08 10:12
Return for Revision	2026-06-08 10:12
Revised	2026-06-21 20:59
Publication Fee Transferred
Second Decision by Editor	2026-06-29 02:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-29 08:40
Articles in Press	2026-06-29 08:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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