Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	121842
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Microscopic evaluation of giant peritoneal loose body: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Ming Lou, Tian-Zhe Gao, Chao-Ze Zheng, Hang Yu, Yan-Yun Hong and Xiao-Sun Liu
Funding Agency and Grant Number	Funding Agency Grant Number The Joint TCM Science & Technology Projects of National Demonstration Zones for Comprehensive TCM Reform ZY-KJS-ZJ-2025-052
Corresponding Author	Xiao-Sun Liu, Professor, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 366 Wutong Road, Hangzhou 310000, Zhejiang Province, China. xiaosunliu@zju.edu.cn
Key Words	Peritoneal loose body; Microbiota; Arachidonic acid; Palmitoylethanolamide; Inflammatory microenvironment; Case report
Core Tip	An instance of a giant peritoneal loose body (PLB) is described. We, for the first time, examined the interior microbial composition and metabolite profile using metagenomic sequencing and liquid chromatography–mass spectrometry. Arachidonic acid and palmitoylethanolamide, the two lipid bioactive mediators, were found along with microorganisms such as Aspergillus, Acinetobacter and Aeromonas. We speculate that continuous stimulation by fat necrosis and microorganisms on abdominal macrophages may be the fundamental cause of giant PLB formation.
Citation	Lou YM, Gao TZ, Zheng CZ, Yu H, Hong YY, Liu XS. Microscopic evaluation of giant peritoneal loose body: A case report. World J Gastrointest Surg 2026; In press

Received	2026-04-02 07:20
Peer-Review Started	2026-04-02 07:20
First Decision by Editorial Office Director	2026-05-18 03:03
Return for Revision	2026-05-19 02:40
Revised	2026-06-01 01:24
Publication Fee Transferred	2026-06-05 06:06
Second Decision by Editor	2026-07-16 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-16 05:49
Articles in Press	2026-07-16 05:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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