Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	121843
DOI	10.4251/wjgo.121843
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Li Ma, Meng-Fei Hao, Mu-Xi Chen, Yu-Jie Lu, Jin-Ting Su, Shu Tong, Jia-Wei Wang, Xin Li, Ling-Yu Wei, Wei-Wei Wang, Xiao-Xuan Duan and Jin-Sheng Wang
Funding Agency and Grant Number	Funding Agency Grant Number the Technology Commission Foundation of Shanxi Province 202303021221181 Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College HPYJ202512 Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College HPYJ202215 Youth Start-Up Fund of Affiliated HePing Hospital of Changzhi Medical College HPYJ202223 Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province (Key Laboratory of Esophageal Cancer Basic Research and Clinical Transformation, Heping Hospital Affiliated to Changzhi Medical College) 2020SYS22 the Changzhi Esophageal Cancer Research and Transformation Technology Innovation Center 2022cx003
Corresponding Author	Jin-Sheng Wang, Department of Pathology, HePing Hospital Affiliated to Changzhi Medical College, No. 110, South Yan'an Road, Luzhou District, Changzhi City, Shanxi Province, P.R. China, Changzhi 046000, Shanxi Province, China. wjsczmc@163.com
Key Words	Esophageal squamous cell carcinoma; CHMP2A; Prognosis; Proliferation; Angiogenesis
Core Tip	Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a poor prognosis. This study revealed that CHMP2A is significantly upregulated in ESCC tissues and cell lines, and its high expression predicts poor survival in ESCC patients. Functional assays demonstrated that CHMP2A promotes ESCC cell proliferation, invasion, migration, and tumor angiogenesis. Our findings identify CHMP2A as a novel prognostic biomarker in ESCC, potentially informing new strategies for its diagnosis and treatment.
Citation	Ma LL, Hao MF, Chen MX, Lu YJ, Su JT, Tong S, Wang JW, Li X, Wei LY, Wang WW, Duan XX, Wang JS. CHMP2A as a potential prognostic biomarker for esophageal squamous cell carcinoma promotes tumor angiogenesis and cancer progression. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.121843
PDF	121843-in-press.pdf

Received	2026-04-15 06:57
Peer-Review Started	2026-04-15 06:58
First Decision by Editorial Office Director	2026-04-29 10:16
Return for Revision	2026-04-30 11:06
Revised	2026-05-20 15:19
Publication Fee Transferred	2026-05-24 04:41
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 08:34
Articles in Press	2026-06-22 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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