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Articles in Press
7/7/2026 7:23:29 AM | Browse: 5 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
ALDH2 deficiency in pancreatic acinar cells aggravates acute pancreatitis by promoting NLRP3 inflammasome activation through autophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing-Zhen Wu, Bo-Zong Shao, Hong-Yi Sun, Kai-Yue Guan, Yan Wang, Zhen-Yu Liu, Wen-Gang Zhang and En-Qiang Linghu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Beijing Municipal |
7244297 |
| National Natural Science Foundation of China |
82204483 |
| the Youth Talent Program of the First Medical Center of Chinese PLA General Hospital |
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| Corresponding Author |
En-Qiang Linghu, Chief Physician, MD, PhD, Professor, School of Medicine, Nankai University, No. 94 Weijin Road, Tianjin 300071, China. linghuenqiang@vip.sina.com |
| Key Words |
Acute pancreatitis; Aldehyde dehydrogenase 2; Autophagy; Nod-like receptor family pyrin domain-containing 3 inflammasome; Pancreatic acinar cell |
| Core Tip |
Using caerulein-induced mouse and endoscope-based porcine acute pancreatitis (AP) models, this study found aldehyde dehydrogenase 2 (ALDH2) expression in pancreatic acinar cells increased while activity decreased, accompanied by autophagic substrate accumulation and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation. During AP, ALDH2 deficiency in pancreatic acinar cells exacerbated autophagic substrate accumulation and NLRP3 inflammasome activation in vivo and in vitro. ALDH2 deficiency attenuated rapamycin's inhibition of NLRP3 inflammasome activation, while ALDH2 agonist Alda-1 reduced inflammasome components in an autophagy-dependent manner, as evidenced by chloroquine reversal. These findings link ALDH2, autophagy, and NLRP3 inflammasome regulation in pancreatic acinar cells. |
| Citation |
Wu QZ, Shao BZ, Sun HY, Guan KY, Wang Y, Liu ZY, Zhang WG, Linghu EQ. ALDH2 deficiency in pancreatic acinar cells aggravates acute pancreatitis by promoting NLRP3 inflammasome activation through autophagy. World J Gastroenterol 2026; In press
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Received |
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2026-04-03 03:15 |
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Peer-Review Started |
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2026-04-03 03:16 |
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First Decision by Editorial Office Director |
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2026-04-28 02:41 |
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Return for Revision |
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2026-04-28 02:41 |
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Revised |
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2026-05-12 01:22 |
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Publication Fee Transferred |
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2026-05-15 01:26 |
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Second Decision by Editor |
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2026-07-07 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-07 07:23 |
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Articles in Press |
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2026-07-07 07:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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