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Articles in Press
6/24/2026 8:24:19 AM | Browse: 1 | Download: 0
| Category |
Urology & Nephrology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Immunofluorescence-based reclassification of idiopathic membranoproliferative glomerulonephritis: Insights from a single-center cohort
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rahma Rashid, Ranil H Shrestha, Tabassum Elahi, Shaheera Shakeel and Muhammed Mubarak |
| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com |
| Key Words |
End-stage kidney disease; Membranoproliferative glomerulonephritis; Immune complex-mediated membranoproliferative glomerulonephritis; Complement-mediated membranoproliferative glomerulonephritis; Immunofluorescence |
| Core Tip |
Careful subclassification of membranoproliferative glomerulonephritis (MPGN) using immunofluorescence is essential, as immune complex-mediated MPGN and complement-mediated MPGN (C-MPGN) types differ in underlying mechanisms and outcomes. Although clinical and histopathological features at presentation may appear similar, subtle distinctions, such as stronger C3 deposition and lower serum C3 in C-MPGN, may provide a clue for accurate diagnosis. Immune complex-mediated MPGN is more common and tends to achieve higher remission rates, while C-MPGN may carry a poorer prognosis despite comparable progression to end-stage kidney disease. Long-term follow-up and tailored immunosuppressive strategies are critical for both subtypes to optimize renal outcomes and better understand disease trajectories in diverse populations. |
| Citation |
Rashid R, Shrestha RH, Elahi T, Shakeel S, Mubarak M. Immunofluorescence-based reclassification of idiopathic membranoproliferative glomerulonephritis: Insights from a single-center cohort. World J Nephrol 2026; In press
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| PDF |
121887-in-press.pdf
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Received |
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2026-04-03 08:44 |
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Peer-Review Started |
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2026-04-03 08:46 |
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First Decision by Editorial Office Director |
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2026-05-26 10:12 |
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Return for Revision |
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2026-05-26 10:12 |
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Revised |
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2026-06-05 10:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-24 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-24 08:24 |
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Articles in Press |
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2026-06-24 08:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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