Publication Name	World Journal of Gastroenterology
Manuscript ID	121890
DOI	10.3748/wjg.121890
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression
Manuscript Source	Unsolicited Manuscript
All Author List	Jiao-Qian Lu, Xue-Fen Fang, Xiao-Xiong Guo, Miao Liu, Ji-Hong Lin, Hua-Long Zheng, Can-Mei Zhong, Qiu-Yan Lin, Xiao-Yun Huang, Xiao-Zhong Wang, Hao Tian, Jian-Wen Que, Feng-Lin Chen and Bi-Yun Zheng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China Young Scientists Fund 82203308 National Natural Science Foundation of China General Program 82570660 Fujian Provincial Natural Science Foundation of China 2026J010043 Fujian Provincial Natural Science Foundation of China 2025J01116 Fujian Natural Science Foundation 2023J01651 Young and Middle-Aged Talents Training Project of Fujian Provincial Health Commission 2023GGA018 National Key Clinical Specialty Construction Project of Fujian Province, China 2023-1594
Corresponding Author	Bi-Yun Zheng, Associate Chief Physician, Associate Professor, MD, PhD, Department of Gastroenterology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou 350001, Fujian Province, China. drzhengby@163.com
Key Words	Esophageal squamous cell carcinoma; Heterogeneous nuclear ribonucleoprotein A2/B1; Cyclooxygenase-2; Prostaglandin E2; N6-methyladenosine
Core Tip	Heterogeneous nuclear ribonucleoprotein A2/B1 (HnRNPA2B1) is upregulated in esophageal squamous cell carcinoma and early intraepithelial neoplasia and promotes tumor progression. Mechanistically, hnRNPA2B1 stabilizes cyclooxygenase-2 mRNA in an m6A-related manner, leading to activation of the cyclooxygenase-2/prostaglandin E2 axis. Prostaglandin E2 supplementation rescues the inhibitory effects of hnRNPA2B1 silencing, whereas celecoxib suppresses hnRNPA2B1-driven malignant phenotypes. These findings reveal a novel epitranscriptomic mechanism of esophageal squamous cell carcinoma progression and highlight hnRNPA2B1 as a potential therapeutic target.
Citation	Lu JQ, Fang XF, Guo XX, Liu M, Lin JH, Zheng HL, Zhong CM, Lin QY, Huang XY, Wang XZ, Tian H, Que JW, Chen FL, Zheng BY. Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121890
PDF	121890-in-press.pdf

Received	2026-04-07 06:08
Peer-Review Started	2026-04-07 06:12
First Decision by Editorial Office Director
Return for Revision	2026-06-16 08:59
Revised	2026-06-30 08:52
Publication Fee Transferred	2026-07-12 19:13
Second Decision by Editor	2026-07-20 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-20 05:47
Articles in Press	2026-07-20 05:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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