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Articles in Press
6/9/2026 7:20:07 AM | Browse: 5 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Spatiotemporal atlas of internal hemorrhoids in rats elucidated using integrated single-cell RNA sequencing and spatial transcriptomics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei-Gan Lin, Shu-Yan Huang, Hong Lan, Xia-Xia Zheng, Xian-Bao Liu, Zhen-Guo Xu and Min-Hui Ke |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General Program of the National Natural Science Foundation of China |
No. 81774118 |
| Medical Innovation Project of Fujian Provincial Health Commission |
No. 2024CXB013 |
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| Corresponding Author |
Min-Hui Ke, Chief Physician, Full Professor, PhD, Department of Proctology, The Second People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, Fujian Province, China. 48330132@qq.com |
| Key Words |
Internal hemorrhoids; Single-cell RNA sequencing; Spatial transcriptomics; Cellular heterogeneity; Fibrosis |
| Core Tip |
This study integrates single-cell and spatial transcriptomics to reveal spatiotemporal dynamics in rat internal hemorrhoids. Macrophages shift from pro-inflammatory to pro-reparative phenotypes, while fibroblasts differentiate into growth factor-regulated and profibrotic subsets, driving vascular remodeling. Cd74⁺ macrophages act as early inflammatory switches, activating Igfbp5⁺ fibroblasts/protomyofibroblasts via collagen–integrin interactions and the phosphatidylinositol 3-kinase/protein kinase B signaling, thus promoting vascular dilation, inflammation, and fibrosis. These findings provide novel insights into hemorrhoid progression from inflammation to extracellular matrix remodeling. |
| Citation |
Lin WG, Huang SY, Lan H, Zheng XX, Liu XB, Xu ZG, Ke MH. Spatiotemporal atlas of internal hemorrhoids in rats elucidated using integrated single-cell RNA sequencing and spatial transcriptomics. World J Gastroenterol 2026; In press
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| PDF |
121893-in-press.pdf
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Received |
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2026-04-07 08:34 |
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Peer-Review Started |
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2026-04-07 08:35 |
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First Decision by Editorial Office Director |
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2026-04-23 10:03 |
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Return for Revision |
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2026-04-23 10:03 |
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Revised |
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2026-05-11 13:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-09 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-09 07:20 |
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Articles in Press |
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2026-06-09 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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