Publication Name	World Journal of Clinical Cases
Manuscript ID	121907
DOI	10.12998/wjcc.121907
Country	India

Category	Orthopedics
Manuscript Type	Review
Article Title	Dickkopf-1 in rheumatoid arthritis: Mechanistic insights, imaging associations, and emerging therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Adithya Vikram Rajesh, Arunagiri Gunasekar, Naveen Jeyaraman, Sanjeevi Bharadwaj, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, Associate Professor, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@drmgrdu.ac.in
Key Words	Dickkopf-1; Rheumatoid arthritis; Wnt/β-catenin; Osteoprotegerin; RANKL; Osteoclastogenesis
Core Tip	Dickkopf-1 (DKK-1) is a key regulator of bone remodeling in rheumatoid arthritis, driving erosion by inhibiting Wnt signaling, suppressing osteoblasts, and enhancing RANKL-mediated osteoclastogenesis. Elevated DKK-1 correlates with inflammation, autoantibodies, disease activity, and imaging indices, while genetic variants modulate risk. Though blockade shows therapeutic promise, safety concerns and assay variability remain. DKK-1 offers a multidimensional biomarker for prognosis, monitoring, and precision-targeted therapy in rheumatoid arthritis.
Citation	Rajesh AV, Gunasekar A, Jeyaraman N, Bharadwaj S, Nallakumarasamy A, Muthu S, Jeyaraman M. Dickkopf-1 in rheumatoid arthritis: Mechanistic insights, imaging associations, and emerging therapeutic strategies. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.121907
PDF	121907-in-press.pdf

Received	2026-04-17 01:09
Peer-Review Started	2026-04-17 01:11
First Decision by Editorial Office Director	2026-04-30 08:53
Return for Revision	2026-04-30 08:53
Revised	2026-05-06 07:08
Publication Fee Transferred
Second Decision by Editor	2026-06-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-09 06:45
Articles in Press	2026-06-09 06:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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