Publication Name	World Journal of Meta-Analysis
Manuscript ID	121918
Country	Lebanon

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Patient-reported outcome assessment in heart failure with preserved ejection fraction: A systematic review of semaglutide trials using the Kansas City Cardiomyopathy Questionnaire
Manuscript Source	Unsolicited Manuscript
All Author List	Razan Abdulaal, Luna Maria Khalil, Ali Hteit, Ehab Al Mashtoub, Mariam Allaw, Lynn Hajj, Abbas Taki and Mohamad Tlais
Funding Agency and Grant Number
Corresponding Author	Mohamad Tlais, Cardiology, University of Balamand, Hazmieh, Beirut 1100, Beyrouth, Lebanon. mmtlaiss22@gmail.com
Key Words	Heart failure with preserved ejection fraction; Kansas City Cardiomyopathy Questionnaire; Patient-reported outcomes; Quality of life; Systematic review
Core Tip	This systematic review demonstrates that semaglutide improves patient-reported quality of life in obesity-related heart failure with preserved ejection fraction, with blinded randomised trials showing approximately 7-8 Kansas City Cardiomyopathy Questionnaire points of benefit over placebo. The threefold larger effect in the open-label observational cohort reflects expectation bias and residual confounding rather than genuine superiority. Methodological heterogeneity across instruments, doses, and study designs limits cross-study comparisons and highlights the urgent need for standardised patient-reported outcome sets and prospective trial registration in this field.
Citation	Abdulaal R, Khalil LM, Hteit A, Mashtoub EA, Allaw M, Hajj L, Taki A, Tlais M. Patient-reported outcome assessment in heart failure with preserved ejection fraction: A systematic review of semaglutide trials using the Kansas City Cardiomyopathy Questionnaire. World J Meta-Anal 2026; In press

Received	2026-04-08 01:22
Peer-Review Started	2026-04-08 01:26
First Decision by Editorial Office Director	2026-04-13 09:23
Return for Revision	2026-04-13 16:26
Revised	2026-04-21 15:52
Publication Fee Transferred
Second Decision by Editor	2026-05-13 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-13 07:54
Articles in Press	2026-05-13 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2308-3840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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