Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	121926
Country	Egypt

Category	Pediatrics
Manuscript Type	Observational Study
Article Title	Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome
Manuscript Source	Invited Manuscript
All Author List	Noura M Ibrahim Elbakry, Mohamed S Hemeda, Ayat Mostafa Mohamed Ahmed, Hager Adel Zaky, Aya Nabil Gamil, Abd Elmoaty Arafat Abd Elmoaty, Mahmoud M Khafagi, Ashraf Mohamed Alkabeer, Aldosoky Abd Elaziz Alsaid, Ahmed A Elhagary, Walid Mohammed Aboassy and Ahmed Nabil Gamil Mohammed
Funding Agency and Grant Number
Corresponding Author	Mohamed S Hemeda, Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said 44654, Egypt. mohamudsadawy@med.psu.edu.eg
Key Words	Helicobacter pylori; Childhood obesity; Metabolic syndrome phenotype; Insulin resistance; Homeostasis model assessment of insulin resistance; Tumor necrosis factor-alpha; Dyslipidemia
Core Tip	In obese children and adolescents with a metabolic syndrome phenotype, Helicobacter pylori (H. pylori) positivity was associated with higher homeostasis model assessment of insulin resistance, higher tumor necrosis factor-alpha, a more atherogenic lipid profile, elevated liver enzymes, hepatomegaly, and higher rates of elevated blood pressure. Several associations remained significant after adjustment for age, sex, and standardized body mass index value. These findings suggest that H. pylori positivity may mark a greater inflammatory and metabolic burden in high-risk pediatric obesity, while causality still requires confirmation in prospective studies.
Citation	Ibrahim Elbakry NM, Hemeda MS, Mostafa Mohamed Ahmed A, Adel Zaky H, Gamil AN, Arafat Abd Elmoaty AE, M. Khafagi M, Mohamed Alkabeer A, Abd Elaziz Alsaid A, A. Elhagary A, Mohammed Aboassy W, Nabil Gamil Mohammed A. Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome. World J Clin Pediatr 2026; In press

Received	2026-04-07 07:05
Peer-Review Started	2026-04-07 07:06
First Decision by Editorial Office Director	2026-04-17 08:16
Return for Revision	2026-04-17 08:16
Revised	2026-04-20 16:22
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 07:54
Articles in Press	2026-05-06 07:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com