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Publication Name World Journal of Virology
Manuscript ID 121928
DOI 10.5501/wjv.121928
Country Sri Lanka
Category Virology
Manuscript Type Retrospective Study
Article Title Emerging evidence of sand fly fever virus transmission in Sri Lanka
Manuscript Source Invited Manuscript
All Author List Thulani Pattiyakumbura, Erandi Ekanayake, Nipuni Arachchige, Achini Weerathunga, Dhanushka Dasanayake and Rohitha Muthugala
Funding Agency and Grant Number
Funding Agency Grant Number
Medical Research Institute Research Budget Project No. 08/RC/2022
Corresponding Author Rohitha Muthugala, Consultant, MD, Department of Molecular Biology, Medical Research Institute, No. 527 Dr. Danister De Silva Mawatha, Colombo 00800, Western, Sri Lanka. rohithavm@yahoo.com
Key Words Sand fly fever virus; Sri Lanka; Dengue; Acute febrile illness; Sandfly
Core Tip Sand fly fever virus (SFFV) infection is an acute self-limiting febrile illness caused by Phleboviruses and transmitted by sand flies of the Phlebotomus species. Clinically, SFFV infection closely resembles acute dengue fever and specific laboratory tests are required to diagnose SSFV. In Sri Lanka, a certain proportion of clinically suspected dengue patients were negative for dengue by laboratory investigation. We conducted this study to detect other possible pathogens in a group of patients admitted to hospitals with clinically dengue like illness. Seven hundred and fifty-seven patients’ samples were tested and two samples were positive for immunoglobulin M antibodies against SFFV, indicating recent or acute infection. The clinical and laboratory features of these patients were similar to those of uncomplicated dengue fever. Both patients were tested negative for flavivirus, alphaviruses, hantaviruses and leptospirosis. This study provides the first evidence of SFFV infection in Sri Lanka. As dengue fever is highly endemic in the country, SFFV infections may often be misdiagnosed as dengue and remain undetected. Further studies on febrile patients and sand fly vectors are needed to determine the disease burden and support effective control measures.
Citation Pattiyakumbura T, Ekanayake E, Arachchige N, Weerathunga A, Dasanayake D, Muthugala R. Emerging evidence of sand fly fever virus transmission in Sri Lanka. World J Virol 2026; In press
PDF 121928-in-press.pdf
Received
2026-04-07 07:24
Peer-Review Started
2026-04-07 07:25
First Decision by Editorial Office Director
2026-06-02 13:08
Return for Revision
2026-06-02 13:08
Revised
2026-06-09 17:31
Publication Fee Transferred
Second Decision by Editor
2026-06-29 02:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-29 08:03
Articles in Press
2026-06-29 08:03
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-3249 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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