Publication Name	World Journal of Gastroenterology
Manuscript ID	121944
DOI	10.3748/wjg.121944
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Bridge of imbalance: How does the brain-gut axis act as a catalyst for gastrointestinal tumors in aging
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Xu, Cheng-Kang Qu, Ling-Ling Bao, Yu-Xuan Zhang, Wen-Juan Wang and Ying-Quan Ye
Funding Agency and Grant Number
Corresponding Author	Wen-Juan Wang, Department of Hematology and Oncology, Beilun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 1288 East Lushan Road, Beilun District, Ningbo 315800, Zhejiang Province, China. wwjwjbwsy@163.com
Key Words	Brain-gut axis; Aging; Gastrointestinal tumors; Gut microbiota; Central nervous system
Core Tip	Aging remodels the brain-gut axis, creating a catalyst for gastrointestinal tumors. Key mechanisms include gut microbiota dysbiosis, neurotransmitter imbalance (e.g., 5-hydroxytryptamine, norepinephrine), neuroendocrine dysregulation, inflammaging, and circadian rhythm disruption. These factors remodel the tumor microenvironment, promote chronic inflammation, and drive tumorigenesis. Targeting the gut microbiota, neurotransmitter pathways, and circadian clocks offers emerging therapeutic strategies for aging-related gastrointestinal cancers.
Citation	Xu X, Qu CK, Bao LL, Zhang YX, Wang WJ, Ye YQ. Bridge of imbalance: How does the brain-gut axis act as a catalyst for gastrointestinal tumors in aging. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121944
PDF	121944-in-press.pdf

Received	2026-04-07 03:11
Peer-Review Started	2026-04-07 03:20
First Decision by Editorial Office Director	2026-04-28 02:44
Return for Revision	2026-04-28 02:44
Revised	2026-06-01 14:07
Publication Fee Transferred	2026-06-07 14:46
Second Decision by Editor	2026-06-23 02:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-23 05:37
Articles in Press	2026-06-23 05:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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