Publication Name	World Journal of Psychiatry
Manuscript ID	121968
DOI	10.5498/wjp.121968
Country	China

Category	Psychology
Manuscript Type	Retrospective Study
Article Title	Post-stroke depression on prognosis of stroke-associated pneumonia and analysis of predictive factors: A retrospective study of 186 patients
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Li Zhang, Jie Liu, Kai Wei, Chun-Na Hu, Xiao-Jun Wang, Qing-Lin Han and Li-Chun Wang
Funding Agency and Grant Number	Funding Agency Grant Number Hebei Provincial Science Research Project Plan for Traditional Chinese Medicine 2025563
Corresponding Author	Li-Chun Wang, Department of Rehabilitation Medicine, Cangzhou Hospital of Integrated TCM-WM · Hebei, No. 31, Huanghe Road, Cangzhou City, Hebei Province, Cangzhou 061001, Hebei Province, China. wlc20040630@sina.com
Key Words	Stroke-associated pneumonia; Post-stroke depression; Prognosis; Predictive factors; Warm moxibustion; Brain-derived neurotrophic factor
Core Tip	This retrospective study of 186 stroke-associated pneumonia (SAP) patients demonstrates that co-morbid post-stroke depression is highly prevalent (approximately 50% of SAP) and an independent predictor of adverse prognosis, including markedly longer time to resolution of infection, prolonged hospital stays and worse functional recovery at discharge as well as higher 28-day mortality. A robust seven-variable predictor model, incorporating depression status, disease severity indices (Acute Physiology and Chronic Health Evaluation II), nutritional biomarkers (albumin), infectious parameters (multi-drug resistant organism status), neurotrophic factors (brain-derived neurotrophic factor), mechanical ventilation duration, and age, yielded excellent discriminative power with an area under the curve of 0.91, representing a clinically actionable framework for early identification of high-risk SAP patients. Conclusions routine depression screening appears to be important in SAP management, and integrated traditional Chinese and Western medicine approaches, especially warm moxibustion, may have superior effects.
Citation	Zhang HL, Liu J, Wei K, Hu CN, Wang XJ, Han QL, Wang LC. Post-stroke depression on prognosis of stroke-associated pneumonia and analysis of predictive factors: A retrospective study of 186 patients. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.121968
PDF	121968-in-press.pdf

Received	2026-05-12 11:00
Peer-Review Started	2026-05-12 11:00
First Decision by Editorial Office Director	2026-06-04 07:26
Return for Revision	2026-06-04 07:26
Revised	2026-07-04 04:23
Publication Fee Transferred	2026-07-13 09:46
Second Decision by Editor	2026-08-05 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:45
Articles in Press	2026-08-05 10:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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