Publication Name	World Journal of Gastroenterology
Manuscript ID	121972
DOI	10.3748/wjg.121972
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Applications of nanozymes in the diagnosis and treatment of gastrointestinal malignancies
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Cui Tang, Ru-Ping Gao, Yu-Xi Lv, Yu Wang and Xiao-Bo Guo
Funding Agency and Grant Number
Corresponding Author	Xiao-Bo Guo, MD, Professor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jingshi Road, Jinan 250101, Shandong Province, China. guo992352@hotmail.com
Key Words	Nanozymes; Diagnosis; Treatment; Gastric cancer; Colorectal cancer
Core Tip	Nanozymes, with their enzyme-mimicking catalytic activity, have demonstrated high sensitivity and stability in tumor marker detection, molecular imaging diagnosis, and pathological staining. Additionally, they achieve synergistic therapy for gastrointestinal (GI) malignancies through the generation of reactive oxygen species, regulation of the immune microenvironment, and as multifunctional drug carriers. Despite challenges remaining in biosafety, targeting, and clinical translation, they offer a new strategy for the early diagnosis and precise treatment of GI malignancies.
Citation	Tang YC, Gao RP, Lv YX, Wang Y, Guo XB. Applications of nanozymes in the diagnosis and treatment of gastrointestinal malignancies. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.121972
PDF	121972-in-press.pdf

Received	2026-04-07 02:12
Peer-Review Started	2026-04-07 02:14
First Decision by Editorial Office Director	2026-05-29 06:48
Return for Revision	2026-05-29 06:48
Revised	2026-06-12 02:47
Publication Fee Transferred	2026-07-10 15:31
Second Decision by Editor	2026-07-20 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-20 05:26
Articles in Press	2026-07-20 05:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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