Publication Name	Artificial Intelligence in Gastroenterology
Manuscript ID	121977
DOI	10.35712/aig.121977
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Digital twins in gastroenterology: From computational modeling to precision medicine and clinical translation
Manuscript Source	Invited Manuscript
All Author List	Rishi Chowdhary, Yousra Iftequar, FNU Anveshak, Anushri Parikh, Kridhay Jindal, Kirti Arora and Rahul Chowdhary
Funding Agency and Grant Number
Corresponding Author	Rishi Chowdhary, Department of Medicine, MetroHealth Medical Center, Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA., Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. rxc822@case.edu, Cleveland, 44109, United States. rxc822@case.edu
Key Words	Digital twin; Virtual patient; Personalized medicine; Computational modeling; Systems biology; In silico modeling; Artificial intelligence; Machine learning; Predictive modeling
Core Tip	Digital twins are a transformative shift in the field of gastroenterology as they allow dynamic, patient-specific virtual models that combine multimodal clinical, imaging and multi-omics data to mimic disease evolution and response to therapy. Digital twins provide a pathway for truly personalized and predictive care, as they can be updated in real-time and used for in silico testing of intervention strategies, unlike traditional predictive models. Emerging applications in hepatology, gastrointestinal oncology, inflammatory bowel disease, motility disorders and microbiome science underscore their potential. However, challenges related to data integration, validation, scalability and ethical governance need to be addressed before clinical implementation.
Citation	Chowdhary Ri, Iftequar Y, Anveshak F, Parikh A, Jindal K, Arora K, Chowdhary Ra. Digital twins in gastroenterology: From computational modeling to precision medicine and clinical translation. Artif Intell Gastroenterol 2026; In press DOI: https://doi.org/10.35712/aig.121977
PDF	121977-in-press.pdf

Received	2026-04-10 06:09
Peer-Review Started	2026-04-10 06:10
First Decision by Editorial Office Director	2026-05-20 10:24
Return for Revision	2026-05-20 10:24
Revised	2026-05-25 14:38
Publication Fee Transferred
Second Decision by Editor	2026-06-23 02:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-23 06:35
Articles in Press	2026-06-23 06:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2644-3236 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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