| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hazar S Alharbi, Ishrat Rahman, Manal A AlSheddi, Hanan Henidi, Manal Mubarak Alkahtani, Zaha Al Makhlafi, Sahar ElRefai, Shams A Altwaim, Hourya Sanat Alnofaie, Hend M Salem, Maha Galal Omar, Alia Alturki, Hiba Talic, Ghada Aladhyani, Fotoon Alotaibi, Hadeel Basuhail, Rasil Alotaibi, Nada Alturki, Aljawhara Alharbi, Rafa Alsultan and Sara Khalid Albassam |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Sara Khalid Albassam, Assistant Professor, Department of Basic Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, Airport Road, Riyadh 11671, Saudi Arabia. skalbassam@pnu.edu.sa |
| Key Words |
Platinum drugs; Chemotherapy; Oxygen; Apoptosis; Cytotoxic |
| Core Tip |
Curcumin retained cytotoxic activity in oral squamous cell carcinoma under hypoxic, chemoresistant conditions where carboplatin activity declined. Its effects were associated with apoptosis induction and reduced reactive oxygen species, suggesting cytotoxicity that may not depend solely on increased oxidative stress. However, curcumin also increased cancer stem cell-associated marker expression, particularly under hypoxia. This marker enrichment may reflect selective survival, phenotypic adaptation, or stress-induced reprogramming, but functional validation is required. These findings highlight the importance of hypoxia in shaping drug response and treatment-associated cellular adaptation in oral squamous cell carcinoma. |
| Citation |
Alharbi HS, Rahman I, AlSheddi MA, Henidi H, Alkahtani MM, Al Makhlafi Z, ElRefai S, Altwaim SA, Alnofaie HS, Salem HM, Omar MG, Alturki A, Talic H, Aladhyani G, Alotaibi F, Basuhail H, Alotaibi R, Alturki N, Alharbi A, Alsultan R, Albassam SK. Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma. World J Stem Cells 2026; In press
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| PDF |
121991-in-press.pdf
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