Publication Name	World Journal of Clinical Oncology
Manuscript ID	121993
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Harnessing minimal residual disease for precision medicine in locally advanced gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Xiao-Wei Guo, Xin-Xin Xu, Bing-Jie Deng, Guang-Fu Zhou, Qian Zhou, Xiao-Xin Gao, Cheng-Zhou Du, Zhi Qiao and Hong-Tao Li
Funding Agency and Grant Number	Funding Agency Grant Number Military Health Care Project 24BJZ15 Gansu Provincial Science and Technology Project 25JRRA1191
Corresponding Author	Hong-Tao Li, Associate Chief Physician, Associate Professor, Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, No. 333 South River Road, Lanzhou 730050, Gansu Province, China. lihongtao528@163.com
Key Words	Locally advanced gastric cancer; Minimal residual disease; Circulating tumor DNA; Recurrence prediction; Treatment guidance; Neoadjuvant therapy
Core Tip	Locally advanced gastric cancer remains difficult to cure because occult residual disease can drive recurrence after radical or multimodal therapy. Minimal residual disease (MRD) assessment using circulating tumor DNA (ctDNA) offers a non-invasive strategy for molecular surveillance, recurrence-risk stratification, and dynamic evaluation of treatment response. This minireview highlights current ctDNA-MRD technologies, introduces tumor-informed and tumor-agnostic approaches, and clarifies that ctDNA-MRD is promising but still investigational for treatment guidance. Standardized assays, validated thresholds, and prospective interventional trials are needed before routine precision management of locally advanced gastric cancer.
Citation	Guo XW, Xu XX, Deng BJ, Zhou GF, Zhou Q, Gao XX, Du CZ, Qiao Z, Li HT. Harnessing minimal residual disease for precision medicine in locally advanced gastric cancer. World J ClinOncol 2026; In press

Received	2026-04-08 03:35
Peer-Review Started	2026-04-08 03:37
First Decision by Editorial Office Director	2026-05-27 08:13
Return for Revision	2026-05-27 09:11
Revised	2026-06-10 08:39
Publication Fee Transferred
Second Decision by Editor	2026-06-25 02:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-25 02:58
Articles in Press	2026-06-25 02:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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