Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	122029
DOI	10.4291/wjgp.122029
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Gut barrier dysfunction and multidrug-resistant bacterial translocation in adult critical illness: Mechanistic insights from a systematic review
Manuscript Source	Invited Manuscript
All Author List	Shree V Dhotre, Pradnya S Dhotre, Sachin S Mumbre and Basavraj S Nagoba
Funding Agency and Grant Number
Corresponding Author	Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. basavraj.nagoba@mimsr.edu.in
Key Words	Gut barrier dysfunction; Tight junctions; Multidrug-resistant bacteria; Carbapenem-resistant Enterobacteriaceae; Bacterial translocation; Critical illness; Sepsis; Gut microbiome dysbiosis
Core Tip	Intestinal colonization with multidrug-resistant organisms often precedes bloodstream infection in critically ill adults. Findings from clinical cohorts, microbiome analyses, and biomarker studies indicate that disruption of epithelial barrier integrity and loss of microbiome-mediated colonization resistance may increase the risk of systemic infection. However, most available evidence is observational and remains susceptible to confounding, particularly from antibiotic exposure, illness severity, and intensive care units-related factors. This PRISMA-compliant systematic review brings together mechanistic and clinical evidence, with careful appraisal of study quality, and identifies gut barrier dysfunction as a plausible - though not definitively causal - contributor to antimicrobial resistance-associated infections, highlighting important directions for future research.
Citation	Dhotre SV, Dhotre PS, Mumbre SS, Nagoba BS. Gut barrier dysfunction and multidrug-resistant bacterial translocation in adult critical illness: Mechanistic insights from a systematic review. World J Gastrointest Pathophysiol 2026; In press DOI: https://doi.org/10.4291/wjgp.122029
PDF	122029-in-press.pdf

Received	2026-04-08 03:28
Peer-Review Started	2026-04-08 03:28
First Decision by Editorial Office Director	2026-04-23 05:03
Return for Revision	2026-04-23 05:03
Revised	2026-05-02 06:39
Publication Fee Transferred
Second Decision by Editor	2026-06-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-11 06:48
Articles in Press	2026-06-11 06:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2026-06-11 10:17

ISSN	2150-5330 (online)
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