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Articles in Press
9/18/2026 10:31:43 AM | Browse: 3 | Download: 0
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Carnitine palmitoyltransferase 1A facilitates the senescence of human dental pulp stem cells by Parkin succinylation-mediated mitophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Chi Lv, Yu-Feng Fan and Xue-Jun Ge |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project Task Book for Shanxi Provincial Basic Research Program |
202303021211127 |
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| Corresponding Author |
Xue-Jun Ge, Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, No. 56 Xinjiannan Road, Yingze District, Taiyuan 030001, Shanxi Province, China. gxj19722003@163.com |
| Key Words |
Dental pulp stem cells; Senescence; Carnitine palmitoyltransferase 1A; Succinylation; Mitophagy; Parkin |
| Core Tip |
This study reveals that carnitine palmitoyltransferase 1A (CPT1A) promotes senescence of human dental pulp stem cells (DPSCs) by inhibiting Parkin-mediated mitophagy. CPT1A is upregulated in senescent late-passage DPSCs, and its knockdown suppresses senescence while enhancing mitophagy. Mechanistically, CPT1A acts as a succinyltransferase that succinylates Parkin protein at lysine 27, reducing Parkin stability. Silencing CPT1A decreases Parkin succinylation, stabilizes Parkin, and restores mitophagy. In vivo, CPT1A knockdown alleviates D galactose-induced dental pulp aging via Parkin-dependent mitophagy. This research identifies a novel CPT1A-Parkin succinylation axis controlling DPSC senescence. |
| Citation |
Lv HC, Fan YF, Ge XJ. Carnitine palmitoyltransferase 1A facilitates the senescence of human dental pulp stem cells by Parkin succinylation-mediated mitophagy. World J Stem Cells 2026; In press
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| PDF |
122036-in-press.pdf
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Received |
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2026-04-08 01:58 |
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Peer-Review Started |
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2026-04-08 01:59 |
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First Decision by Editorial Office Director |
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2026-04-16 07:35 |
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Return for Revision |
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2026-04-16 07:35 |
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Revised |
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2026-06-16 06:46 |
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Publication Fee Transferred |
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2026-08-13 02:11 |
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Second Decision by Editor |
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2026-08-24 06:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-18 10:31 |
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Articles in Press |
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2026-09-18 10:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
