Publication Name	World Journal of Stem Cells
Manuscript ID	122048
DOI	10.4252/wjsc.122048
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Systematic Reviews
Article Title	Efficacy and safety of cell-based regenerative therapies for fistula-related diseases: An umbrella review of systematic reviews
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Long Duan, Yong-Hao Wen, Si-Ai Chen, Ru Nie, Ming-Quan Pang, Man-Jun Deng, Zhi-Xin Wang and Hai-Ning Fan
Funding Agency and Grant Number	Funding Agency Grant Number Fourth “Qinghai Scholar” Program 2025-qhxz-fhn
Corresponding Author	Hai-Ning Fan, Chief Physician, Full Professor, PhD, Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. fanhaining@medmail.com.cn
Key Words	Regenerative therapy; Mesenchymal stem cells; Platelet-rich plasma; Perianal fistulas; Fistulizing Crohn’s disease
Core Tip	This umbrella review demonstrates that mesenchymal stem cells (MSCs) based regenerative therapy is associated with meaningful improvements in healing and remission in perianal fistulas and fistulizing Crohn’s disease. The most consistent benefits were observed with adipose-derived, allogeneic, and locally injected MSC. MSC therapy was generally well tolerated, with no increase in overall adverse events and potential reduction in serious adverse events. Among currently studied regenerative approaches, MSC appears to be the most promising option for fistula-related diseases.
Citation	Duan YL, Wen YH, Chen SA, Nie R, Pang MQ, Deng MJ, Wang ZX, Fan HN. Efficacy and safety of cell-based regenerative therapies for fistula-related diseases: An umbrella review of systematic reviews. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.122048
PDF	122048-in-press.pdf

Received	2026-04-08 01:38
Peer-Review Started	2026-04-08 01:40
First Decision by Editorial Office Director	2026-04-23 10:10
Return for Revision	2026-04-24 12:19
Revised	2026-05-13 07:42
Publication Fee Transferred	2026-05-20 06:19
Second Decision by Editor	2026-06-17 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-18 08:26
Articles in Press	2026-06-18 08:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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