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Articles in Press
5/19/2026 10:52:25 AM | Browse: 8 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Value of dual energy computed tomography with material decomposition algoritlun in assessing intestinal creeping fat in Crohn’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Wei Dong, Hui-Juan Chen, Chao-Chao Chen and Cheng Lan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82060102 and No.82560109 |
| Natural Science Foundation of Hainan Province, High-level Personnel Program |
No. 822RC818 |
| Research Project of Health Industry in Hainan Province |
No. 20A200172 |
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| Corresponding Author |
Cheng Lan, Chief Physician, MD, Professor, Department of Gastroenterology, Hainan General Hospital, Hainan Medical University Hainan Hospital, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China. lancheng71@163.com |
| Key Words |
Dual-source computed tomography; Crohn’s disease; Creeping fat; Peroxisome proliferator-activated receptor gamma 2; Occludin |
| Core Tip |
This study evaluated the use of dual-source computed tomography with the material decomposition algorithm to quantify intestinal creeping fat (CrF) in Crohn’s disease (CD). Patients with active and quiescent CD underwent clinical, endoscopic, and imaging assessments. Our results demonstrate that the volume of CrF strongly correlates with clinical, endoscopic, and histological scores for both inflammation and fibrosis. Moreover, we also find that higher CrF volume is associated with increased expression of the adipogenic factor peroxisome proliferator-activated receptor gamma 2 and reduced levels of the barrier protein occludin, providing a valuable non-invasive tool for assessing the disease activity and treatment response. |
| Citation |
Dong LW, Chen HJ, Chen CC, Lan C. Value of dual energy computed tomography with material decomposition algoritlun in assessing intestinal creeping fat in Crohn’s disease. World J Radiol 2026; In press |
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Received |
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2026-04-14 09:50 |
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Peer-Review Started |
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2026-04-14 09:50 |
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First Decision by Editorial Office Director |
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2026-04-29 09:07 |
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Return for Revision |
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2026-04-29 09:07 |
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Revised |
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2026-05-10 09:32 |
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Publication Fee Transferred |
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2026-05-11 14:59 |
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Second Decision by Editor |
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2026-05-19 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-19 10:52 |
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Articles in Press |
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2026-05-19 10:52 |
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Edit the Manuscript by Language Editor |
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2026-05-20 02:53 |
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Typeset the Manuscript |
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| ISSN |
1949-8470 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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