Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	122059
DOI	10.5409/wjcp.122059
Country	India

Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Deciphering Kawasaki disease genetics through next generation sequencing: A scoping review
Manuscript Source	Invited Manuscript
All Author List	Anoop Kumar, Vaishali Thakur, Manpreet Dhaliwal, Taranpreet Kaur, Khem Raj, Jayakanthan Kabeerdoss, Amit Rawat and Rakesh Kumar Pilania
Funding Agency and Grant Number	Funding Agency Grant Number Indian Council of Medical Research, New Delhi, India IIRP-2023-0409
Corresponding Author	Rakesh Kumar Pilania, Associate Professor, DM, MD, Pediatric Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, APC 4A, 4127, Advanced Pediatrics, Chandigarh 160012, Chandīgarh, India. kumarpilania007@gmail.com
Key Words	Kawasaki disease; Whole genome sequencing; Whole exome sequencing; Coronary artery abnormalities; Genetic susceptibility; Intravenous immunoglobulin resistance
Core Tip	Whole exome sequencing and whole-genome sequencing are emerging as important tools for understanding the genetic basis of Kawasaki disease (KD). This review summarises current evidence showing how these techniques help identify key genes, immune pathways, and factors linked with coronary artery complications and intravenous immunoglobulin resistance. The findings suggest that KD is a genetically complex and heterogeneous disease involving multiple immune and vascular pathways. These insights are useful for improving risk prediction and guiding personalised treatment. Further large-scale studies in diverse populations are required to translate these findings into routine clinical practice.
Citation	Kumar A, Thakur V, Dhaliwal M, Kaur T, Raj K, Kabeerdoss J, Rawat A, Pilania RK. Deciphering Kawasaki disease genetics through next generation sequencing: A scoping review. World J Clin Pediatr 2026; In press DOI: https://doi.org/10.5409/wjcp.122059
PDF	122059-in-press.pdf

Received	2026-04-14 03:42
Peer-Review Started	2026-04-14 03:42
First Decision by Editorial Office Director	2026-05-25 05:59
Return for Revision	2026-05-25 05:59
Revised	2026-06-30 10:15
Publication Fee Transferred
Second Decision by Editor	2026-07-23 07:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:17
Articles in Press	2026-07-28 13:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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