Publication Name	World Journal of Critical Care Medicine
Manuscript ID	122062
DOI	10.5492/wjccm.122062
Country	Canada

Category	Critical Care Medicine
Manuscript Type	Systematic Reviews
Article Title	Characterizing the molecular landscape of venous congestion
Manuscript Source	Invited Manuscript
All Author List	Logan R Van Nynatten, Karina Nabieva, Gemma Barber, Jonathan J Moroniti, Alla Iansavitchene, Ross Prager, Marat Slessarev, John Basmaji and Aleksandra Leligdowicz
Funding Agency and Grant Number
Corresponding Author	Aleksandra Leligdowicz, Critical Care Medicine, Western University, Robarts Research Institute, 100 Perth Dr, Room 4220, London, ON, Canada, N6A 3K7, London N6A5A5, Ontario, Canada. aleks.leligdowicz@lhsc.on.ca
Key Words	Biomarkers; Venous congestion; Proteomics; Ultrasound; Critical care
Core Tip	Clinicians can increasingly identify venous congestion, but they still do not understand its pathobiology. Although congestion is recognized across multiple disease states, the existing literature is largely confined to isolated protein measurements in congested cardiac populations, leaving its broader molecular biology poorly understood. This review reveals a substantial translational gap between physiologic recognition and biological understanding of venous congestion, highlighting the need for high-dimensional molecular studies to define its mechanisms and therapeutic targets.
Citation	Van Nynatten LR, Nabieva K, Barber G, Moroniti JJ, Iansavichene A, Prager R, Slessarev M, Basmaji J, Leligdowicz A. Characterizing the molecular landscape of venous congestion. World J Crit Care Med 2026; In press DOI: https://doi.org/10.5492/wjccm.122062
PDF	122062-in-press.pdf

Received	2026-04-08 01:08
Peer-Review Started	2026-04-08 01:10
First Decision by Editorial Office Director	2026-06-10 00:36
Return for Revision	2026-06-10 00:36
Revised	2026-06-16 19:42
Publication Fee Transferred
Second Decision by Editor	2026-07-16 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-16 08:42
Articles in Press	2026-07-16 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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