Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	122072
Country	Malaysia

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Appendix in ulcerative colitis pathogenesis and therapy: An updated narrative review
Manuscript Source	Invited Manuscript
All Author List	Omar AbdelGhani, Sherreen Elhariri, Payal Bhatnagar, Htar Htar Aung, Mohamed Abdel Wahab and Nabil Eid
Funding Agency and Grant Number
Corresponding Author	Nabil Eid, Associate Professor, MD, PhD, Department of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words	Ulcerative colitis; Therapeutic appendectomy; Autophagy; Xenophagy; Immune dysregulation
Core Tip	Recent clinical studies indicate the potential of the appendix as an immunological and microbial niche in ulcerative colitis pathogenesis. Induction of immune dysregulation and acceleration of inflammation are associated with autophagy dysfunction in colonic cells, and possibly the appendix. Current evidence suggests the potential of appendectomy as an adjunctive therapeutic strategy, improving remission in selected patients.
Citation	AbdelGhani O, Elhariri S, Bhatnagar P, Aung HH, Abdel Wahab M, Eid N. Appendix in ulcerative colitis pathogenesis and therapy: An updated narrative review. World J Gastrointest Pathophysiol 2026; In press

Received	2026-04-09 03:40
Peer-Review Started	2026-04-09 03:40
First Decision by Editorial Office Director	2026-04-21 09:55
Return for Revision	2026-04-21 09:55
Revised	2026-04-30 04:32
Publication Fee Transferred
Second Decision by Editor	2026-05-13 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-13 08:21
Articles in Press	2026-05-13 08:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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