Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	122076
DOI	10.4240/wjgs.122076
Country	China

Category	Medicine, General & Internal
Manuscript Type	Prospective Study
Article Title	Correlation of postoperative inflammatory markers and clinical outcomes with intraoperative carbon dioxide pneumoperitoneum pressure levels in laparoscopic appendectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Deng, Mei-Ling Luo and Qin-Hua Li
Funding Agency and Grant Number	Funding Agency Grant Number the Self-funded Science and Technology Innovation Project, Foshan City, Guangdong Province 2220001004804
Corresponding Author	Jing Deng, Department of General Surgery, The Fifth People's Hospital of Shunde District, Foshan City (Longjiang Hospital of Shunde District, Foshan City), No. 39 Donghua Road, Longjiang Town, Shunde District, Foshan 528300, Guangdong Province, China. zmc0403@126.com
Key Words	Acute appendicitis; Laparoscopic appendectomy; Carbon dioxide pneumoperitoneum pressure; Inflammatory markers; Clinical efficacy; Randomized controlled trial
Core Tip	This prospective randomized controlled trial included 217 patients. We compared the effects of four different intraoperative carbon dioxide pneumoperitoneum pressures (12-15 mmHg) during laparoscopic appendectomy. The results showed that a 12-mmHg pneumoperitoneum pressure significantly reduced postoperative white blood cell and procalcitonin levels, lowered the score on the numeric pain scale, shortened the time to first ambulation and anal gas expulsion, and reduced the length of hospital stay, without increasing the risk of complications (Clavien-Dindo classification ≤ grade II). The above results confirm that 12 mmHg is the ideal pneumoperitoneum pressure that balances surgical field visibility and accelerates recovery.
Citation	Deng J, Luo ML, Li QH. Correlation of postoperative inflammatory markers and clinical outcomes with intraoperative carbon dioxide pneumoperitoneum pressure levels in laparoscopic appendectomy. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.122076
PDF	122076-in-press.pdf

Received	2026-05-12 11:14
Peer-Review Started	2026-05-12 11:14
First Decision by Editorial Office Director	2026-06-02 08:28
Return for Revision	2026-06-02 08:28
Revised	2026-06-16 02:04
Publication Fee Transferred	2026-06-18 06:37
Second Decision by Editor	2026-07-09 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-09 05:54
Articles in Press	2026-07-09 05:54
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Typeset the Manuscript

ISSN	1948-9366 (online)
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