Publication Name	World Journal of Diabetes
Manuscript ID	122101
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Non-antibody biomarkers for differentiating ketosis-onset diabetes: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Qi Pei, Jie-Ling Ren, Li Zhang, Yan-Xia Gao, Xia Yang, Xiang Liu, Su-Ning Li, Ping Liu and Xiao-Yan Xu
Funding Agency and Grant Number
Corresponding Author	Ping Liu, Professor, Department of Endocrinology, Longgang District People’s Hospital of Shenzhen, No. 53 Aixin Road, Yuyuan Community, Longcheng Subdistrict, Shenzhen 518172, Guangdong Province, China. hanner752003@163.com
Key Words	Ketosis-onset adult diabetes; Latent autoimmune diabetes in adults; Ketosis-prone; Type 2 diabetes mellitus; Non-antibody biomarkers; Retrospective study
Core Tip	This study demonstrates that more than one-quarter of adults presenting with ketosis have latent autoimmune diabetes in adult, highlighting the risk of misclassification. We identify a practical panel of non-antibody biomarkers, including 2 hours C-peptide, high-density lipoprotein cholesterol, gamma-glutamyl transferase, homeostasis model assessment of insulin resistance, alkaline phosphatase, free triiodothyronine, and fasting plasma glucose, that can effectively differentiate latent autoimmune diabetes in adult from ketosis-prone type 2 diabetes mellitus and predict ketosis onset. These readily available indicators provide a cost-effective diagnostic alternative in settings where autoantibody testing is limited, facilitating early classification and personalized treatment strategies.
Citation	Pei SQ, Ren JL, Zhang L, Gao YX, Yang X, Liu X, Li SN, Liu P, Xu XY. Non-antibody biomarkers for differentiating ketosis-onset diabetes: A retrospective study. World J Diabetes 2026; In press

Received	2026-04-10 00:42
Peer-Review Started	2026-04-12 23:55
First Decision by Editorial Office Director	2026-04-29 10:33
Return for Revision	2026-04-29 10:33
Revised	2026-05-13 07:54
Publication Fee Transferred	2026-05-21 05:41
Second Decision by Editor	2026-06-17 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-03 05:59
Articles in Press	2026-07-03 05:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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