Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	122124
DOI	10.4253/wjge.122124
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	From surface to depth: Combining white-light and ultrasound endoscopy to predict complete response in rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Chi, Jun Weng, Wei-Hao Li, Kun-Hao Bai, Rong Yang, Lin-Jie Zhang, Wen-Hua Fan and Xiao-Jun Wu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82403973
Corresponding Author	Xiao-Jun Wu, Chief Physician, MD, Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. wuxj@sysucc.org.cn
Key Words	Locally advanced rectal cancer; Neoadjuvant chemoradiotherapy; Watch and Wait strategy; Complete response; White light endoscopy; Endoscopic ultrasound
Core Tip	Accurately identifying a complete response (CR) in patients diagnosed with locally advanced rectal cancer undergoing neoadjuvant treatment is the main challenge for adopting the “Watch and Wait” strategy. By combining white light endoscopy and endoscopic ultrasound features, we constructed a “surface-to-depth” nomogram achieving an area under the curve of 0.829 (95% confidence interval: 0.748-0.909) to predict CR. This integrated model provides clinicians with a practical, minimally invasive tool to select eligible candidates who might obtain clinic benefit from organ preservation management.
Citation	Chi J, Weng J, Li WH, Bai KH, Yang R, Zhang LJ, Fan WH, Wu XJ. From surface to depth: Combining white-light and ultrasound endoscopy to predict complete response in rectal cancer. World J Gastrointest Endosc 2026; In press DOI: https://doi.org/10.4253/wjge.122124
PDF	122124-in-press.pdf

Received	2026-04-14 03:14
Peer-Review Started	2026-04-14 03:14
First Decision by Editorial Office Director
Return for Revision	2026-06-27 14:08
Revised	2026-07-07 13:39
Publication Fee Transferred	2026-07-13 12:52
Second Decision by Editor	2026-07-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:20
Articles in Press	2026-07-28 13:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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