Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	122166
DOI	10.5409/wjcp.122166
Country	India

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Non-nutritional rickets: Approach, precision medicine, and outcomes
Manuscript Source	Invited Manuscript
All Author List	Pratyush Prateek Pathak and Sayantan Ray
Funding Agency and Grant Number
Corresponding Author	Sayantan Ray, Assistant Professor, Department of Endocrinology, All India Institute of Medical Sciences, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. sayantan.ray30@gmail.com
Key Words	Calcium; Vitamin D; Calciopenic rickets; Hypophosphatemic rickets; Algorithm; Fibroblast growth factor 23
Core Tip	Non-nutritional rickets represent a heterogeneous group of disorders. Presentation before 6 months or after 2 years of age, stigmata of specific systemic illnesses, and lack of response to oral calcium and vitamin D should raise clinical suspicion. A systematic diagnostic algorithm can guide evaluation. Parathyroid hormone may serve as a useful initial biochemical discriminator between calciopenic and hypophosphatemic rickets. Fibroblast growth factor 23 assays help distinguish fibroblast growth factor 23-dependent and independent hypophosphatemic rickets subtypes. Levels of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D help sub-classify heritable forms of calciopenic rickets. Several entities require molecular techniques for diagnostic confirmation, enabling precision medicine and genetic counselling.
Citation	Pathak PP, Ray S. Non-nutritional rickets: Approach, precision medicine, and outcomes. World J Clin Pediatr 2026; In press DOI: https://doi.org/10.5409/wjcp.122166
PDF	122166-in-press.pdf

Received	2026-04-13 05:50
Peer-Review Started	2026-04-13 05:51
First Decision by Editorial Office Director	2026-04-29 10:35
Return for Revision	2026-04-29 10:35
Revised	2026-05-18 13:30
Publication Fee Transferred
Second Decision by Editor	2026-06-04 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-04 05:19
Articles in Press	2026-06-04 05:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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