Publication Name	World Journal of Gastroenterology
Manuscript ID	122218
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Qin Wan, Yi-Ying Wang, Xin-Yu Li, Ying Liu, Bo-Yi Jia and Mei Han
Funding Agency and Grant Number	Funding Agency Grant Number High-Level Traditional Chinese Medicine Key Subjects Construction Project of the National Administration of Traditional Chinese Medicine - Evidence-Based Traditional Chinese Medicine zyyzdxk-2023249
Corresponding Author	Mei Han, Center for Evidence-Based Medicine, Beijing University of Chinese Medicine, No. 11 Beisanhuan East Road, Chaoyang District, Beijing 100029, China. hanmeizouijn@163.com
Key Words	Functional dyspepsia; Traditional Chinese medicine; Aurantii Fructus Immaturus Flavonoid; Optimal dosage; Zhi Shi
Core Tip	This placebo-controlled, randomized phase IIb trial identified, for the first time, the optimal clinical dose of Zhi Shi Flavonoids for functional dyspepsia. Both the medium- and high-dose Aurantii Fructus Immaturus Flavonoid groups showed significant improvement in functional dyspepsia symptomms after 4 weeks compared with the placebo group, with good tolerability and no serious adverse events. These findings inform optimal dosing for phase III trials and support the integration of personalized traditional Chinese medicine into the modern management of gastrointestinal disorders.
Citation	Wan Q, Wang YY, Li XY, Liu Y, Jia BY, Han M. Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial. World J Gastroenterol 2026; In press

Received	2026-04-14 02:39
Peer-Review Started	2026-04-14 02:39
First Decision by Editorial Office Director	2026-05-07 11:32
Return for Revision	2026-05-07 11:32
Revised	2026-06-03 13:59
Publication Fee Transferred	2026-06-05 10:22
Second Decision by Editor	2026-07-03 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-03 07:35
Articles in Press	2026-07-03 07:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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