Publication Name	World Journal of Gastroenterology
Manuscript ID	122240
DOI	10.3748/wjg.122240
Country	Thailand

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Changes in liver and spleen stiffness after transarterial chemoembolization for hepatocellular carcinoma and role in predicting hepatic decompensation
Manuscript Source	Unsolicited Manuscript
All Author List	Chidkamon Pattarawongpaiboon, Panarat Thaimai, Sangdao Boonkaya, Kanteera Sriyudthsak, Salisa Lertsanguansinchai, Prooksa Ananchuensook, Supachaya Sriphoosanaphan, Nutcha Pinjaroen, Sombat Treeprasertsuk, Piyawat Komolmit and Kessarin Thanapirom
Funding Agency and Grant Number	Funding Agency Grant Number The Gastroenterological Association of Thailand (GAT)
Corresponding Author	Kessarin Thanapirom, Associate Professor, MD, PhD, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Krung Thep Maha Nakhon, Thailand. kessarin.t@chula.ac.th
Key Words	Cirrhosis; Hepatic decompensation; Hepatocellular carcinoma; Liver stiffness; Noninvasive tests; Portal hypertension; Spleen stiffness; Transarterial chemoembolization; Two-dimensional shear wave elastography
Core Tip	This prospective study evaluated the changes in liver stiffness measurements (LSM) and spleen stiffness measurements (SSM) assessed by two-dimensional shear wave elastography and transient elastography in patients with hepatocellular carcinoma undergoing transarterial chemoembolization. Both LSM and SSM showed no significant changes on days 10 and days 30 after the procedure. Importantly, baseline SSM was identified as a significant non-invasive predictor of 6-month hepatic decompensation. Incorporating baseline SSM (> 54 kilopascals) alongside the modified albumin-bilirubin grade can serve as a comprehensive preprocedural risk stratification tool, effectively bridging the prognostic gap, particularly in clinically homogeneous patients with preserved liver function.
Citation	Pattarawongpaiboon C, Thaimai P, Boonkaya S, Sriyudthsak K, Lertsanguansinchai S, Ananchuensook P, Sriphoosanaphan S, Pinjaroen N, Treeprasertsuk S, Komolmit P, Thanapirom K. Changes in liver and spleen stiffness after transarterial chemoembolization for hepatocellular carcinoma and role in predicting hepatic decompensation. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122240
PDF	122240-in-press.pdf

Received	2026-04-17 01:11
Peer-Review Started	2026-04-17 01:12
First Decision by Editorial Office Director	2026-05-19 06:33
Return for Revision	2026-05-19 06:33
Revised	2026-06-08 15:46
Publication Fee Transferred	2026-06-10 02:08
Second Decision by Editor	2026-06-25 02:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-25 07:15
Articles in Press	2026-06-25 07:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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