Publication Name	World Journal of Gastroenterology
Manuscript ID	122243
DOI	10.3748/wjg.122243
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effects of berberine-containing vs clarithromycin-containing quadruple therapy on intestinal microbiota during Helicobacter pylori eradication
Manuscript Source	Unsolicited Manuscript
All Author List	Teng-Wei Cai, Zhi-Kai Chen, Zi-Yan Lv, Wen-Jun Jiang, Ye-Yu Sun, Ling-Xiao Jin, Chen-Mei Xia, Qian-Qian Li and Xia Chen
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Science and Technology Program of Traditional Chinese Medicine, China No. 2023ZL784 Wenling Social Development Science and Technology Project, China No. 2024S00303
Corresponding Author	Xia Chen, Chief Physician, Department of Gastroenterology, The First People’s Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, No. 333 Chuan’an South Road, Chengxi Street, Wenling 317500, Zhejiang Province, China. werla@sina.com
Key Words	Helicobacter pylori; Berberine; Clarithromycin; Intestinal flora; Bifidobacterium catenulatum; Blautia; Longicatena
Core Tip	This study compares berberine and clarithromycin-based therapy for Helicobacter pylori (H. pylori) eradication. The two regimens have comparable H. pylori eradication efficacy (80.95% vs 75.00%). Berberine causes milder intestinal flora disturbance, maintains flora homeostasis, enriches beneficial bacteria, and reduces antibiotic resistance risk, serving as a promising alternative for H. pylori eradication, especially in antibiotic-resistant populations.
Citation	Cai TW, Chen ZK, Lv ZY, Jiang WJ, Sun YY, Jin LX, Xia CM, Li QQ, Chen X. Effects of berberine-containing vs clarithromycin-containing quadruple therapy on intestinal microbiota during Helicobacter pylori eradication. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122243
PDF	122243-in-press.pdf

Received	2026-04-14 01:53
Peer-Review Started	2026-04-14 01:53
First Decision by Editorial Office Director	2026-06-01 05:59
Return for Revision	2026-06-01 05:59
Revised	2026-06-15 03:40
Publication Fee Transferred	2026-06-29 09:21
Second Decision by Editor	2026-07-13 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-13 09:12
Articles in Press	2026-07-13 09:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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