Publication Name	World Journal of Hepatology
Manuscript ID	122262
DOI	10.4254/wjh.122262
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Long Huang, Cheng-Gui Wu, Teng-Fei Zhu, Qing-Lin Li, Qing-Sheng Yu, Qi Zhang and Yi Shen
Funding Agency and Grant Number	Funding Agency Grant Number Projects of Anhui Provincial Health Commission AHWJ2023A30146 Scientific Research Projects in Anhui Provincial Colleges and Universities 2024AH050959 Anhui Provincial Natural Science Foundation 2408085MH222
Corresponding Author	Long Huang, MD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. huanglong658@163.com
Key Words	Liver fibrosis; STAT3/MYC/MCL-1 pathway; Network pharmacology; Single-cell RNA sequencing; Hepatic stellate cells
Core Tip	This study comprehensively explored the pharmacological mechanism of a fixed Jianpi Huoxue Formula (FJHF). We integrated single-cell transcriptomics, clinical observations, and in vitro experiments to confirm that FJHF inhibits the STAT3/MYC/MCL-1 pathway, suppresses hepatic stellate cell activation, and ameliorates early biochemical abnormalities in liver fibrosis.
Citation	Huang L, Wu CG, Zhu TF, Li QL, Yu QS, Zhang Q, Shen Y. Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.122262
PDF	122262-in-press.pdf

Received	2026-04-20 07:45
Peer-Review Started	2026-04-20 07:46
First Decision by Editorial Office Director	2026-05-26 05:12
Return for Revision	2026-05-26 05:12
Revised	2026-06-10 16:15
Publication Fee Transferred	2026-06-11 12:25
Second Decision by Editor	2026-07-01 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-01 08:45
Articles in Press	2026-07-01 08:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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