Publication Name	World Journal of Diabetes
Manuscript ID	122293
DOI	10.4239/wjd.122293
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Targeting gut microbiota: Potential mechanisms in the pathogenesis of type 2 diabetes mellitus and emerging translational intervention strategies
Manuscript Source	Unsolicited Manuscript
All Author List	Fu-Jian Xie, Miao Zhang, Wan-Ting Li, Wei-Ye Zhou, Hai-Bei Ma, Yu Xu and Li-Ming Bi
Funding Agency and Grant Number	Funding Agency Grant Number Wuxi “Double Hundred” Young and Middle-aged Medical Top Talents Program No. BJ2023065 Jiangsu Provincial Administration of Traditional Chinese Medicine No. ZZYB21
Corresponding Author	Li-Ming Bi, PhD, Department of Traditional Chinese Medicine Classics, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, No. 8 Zhongnan West Road, Binhu District, Wuxi 214071, Jiangsu Province, China. biliming00@aliyun.com
Key Words	Type 2 diabetes mellitus; Gut microbiota; Traditional Chinese medicine; Treatment; Metabolic diseases
Core Tip	Increasing evidence indicates that gut microbiota plays a critical role in the development of type 2 diabetes mellitus (T2DM). Unlike previous reviews that primarily focus on microbial compositional alterations, this review highlights that functional dysregulation of the gut microbiota is the central driver of T2DM pathogenesis. We propose an integrated metabolic-immune-barrier-endocrine framework linking microbial metabolites, inflammation, intestinal barrier dysfunction, and endocrine signaling to glucose dysregulation. We further summarize emerging microbiota-targeted interventions and their translational potential for personalized T2DM management.
Citation	Xie FJ, Zhang M, Li WT, Zhou WY, Ma HB, Xu Y, Bi LM. Targeting gut microbiota: Potential mechanisms in the pathogenesis of type 2 diabetes mellitus and emerging translational intervention strategies. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.122293
PDF	122293-in-press.pdf

Received	2026-04-17 00:31
Peer-Review Started	2026-04-22 08:59
First Decision by Editorial Office Director
Return for Revision	2026-06-17 08:23
Revised	2026-07-01 05:55
Publication Fee Transferred	2026-07-20 01:41
Second Decision by Editor	2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:16
Articles in Press	2026-07-28 13:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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