Publication Name	World Journal of Psychiatry
Manuscript ID	122295
DOI	10.5498/wjp.122295
Country	China

Category	Psychology
Manuscript Type	Retrospective Study
Article Title	Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Hu, Jin Tao, Yun-Li Jiang and Kai Liu
Funding Agency and Grant Number
Corresponding Author	Kai Liu, Department of Clinical Laboratory and Transfusion Medicine, Traditional Chinese Medicine Hospital Dianjiang Chongqing, No. 502 Gongnong Road, Guixi Street, Chongqing 408300, China. liukai891229@163.com
Key Words	Alzheimer disease; Anxiety; Depression; Interleukin-6; Tumor necrosis factor-alpha; Phosphorylated tau; Biomarkers; Retrospective study
Core Tip	Anxiety and depression are common neuropsychiatric complications that markedly worsen the prognosis, as well as the quality of life in patients with Alzheimer’s disease. This study uncovers that the predictive value for anxiety and depression is improved by combining serum inflammatory markers (interleukin-6 and tumor necrosis factor alpha) with p-tau181 instead of individual biomarkers. These findings highlight the importance of comprehensive biomarker assessment as part of standard of care in Alzheimer’s disease to identify at-risk patients for early treatment.
Citation	Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.122295
PDF	122295-in-press.pdf

Received	2026-05-19 10:54
Peer-Review Started	2026-05-19 10:54
First Decision by Editorial Office Director	2026-06-12 09:35
Return for Revision	2026-06-12 09:35
Revised	2026-06-25 11:01
Publication Fee Transferred
Second Decision by Editor	2026-07-20 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-20 03:29
Articles in Press	2026-07-20 03:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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