Publication Name	World Journal of Experimental Medicine
Manuscript ID	122305
DOI	10.5493/wjem.122305
Country	India

Category	Respiratory System
Manuscript Type	Observational Study
Article Title	Culture conversion and drug susceptibility in drug resistant pulmonary tuberculosis with type II diabetes mellitus on oral regimens
Manuscript Source	Invited Manuscript
All Author List	Yogita Vats, Ajay Kumar Verma, Jyoti Bajpai, Surya Kant, Parul Jain, Darshan Bajaj, Anand Srivastava, Ram Avadh Singh Kushwaha, Santosh Kumar, Rajiv Garg, Ankit Kumar and Akshyaya Pradhan
Funding Agency and Grant Number
Corresponding Author	Jyoti Bajpai, Associate Professor, FCCP, Department of Respiratory Medicine, King George’s Medical University, Shahmina Road, Chowk, Lucknow 226003, Uttar Pradesh, India. jyotibajpai33@gmail.com
Key Words	Multidrug-resistant pulmonary tuberculosis; Type 2 diabetes mellitus; Sputum culture conversion; Drug susceptibility testing; All-oral longer regimen
Core Tip	This study explores how type 2 diabetes mellitus influences the clinical course and treatment response of patients with multidrug-resistant pulmonary tuberculosis receiving all-oral longer regimen. It demonstrates that patients with diabetes present with more severe disease, higher bacillary burden, and distinct drug resistance patterns. A key finding is the significantly delayed sputum culture conversion in diabetic patients as compared to pre-diabetic and non-diabetic groups. This delay is associated with poorer treatment outcomes and higher mortality. In general, the study highlights the critical need for integrated tuberculosis-diabetes management to improve the patient outcomes in high-burden settings.
Citation	Vats Y, Verma AK, Bajpai J, Kant S, Jain P, Bajaj D, Srivastava A, Kushwaha RAS, Kumar S, Garg R, Kumar A, Pradhan A. Culture conversion and drug susceptibility in drug resistant pulmonary tuberculosis with type II diabetes mellitus on oral regimens. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.122305
PDF	122305-in-press.pdf

Received	2026-04-15 06:33
Peer-Review Started	2026-04-15 06:53
First Decision by Editorial Office Director	2026-05-20 10:44
Return for Revision	2026-05-20 10:44
Revised	2026-06-02 11:04
Publication Fee Transferred
Second Decision by Editor	2026-07-02 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-02 07:53
Articles in Press	2026-07-02 07:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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