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Publication Name World Journal of Gastroenterology
Manuscript ID 122311
DOI 10.3748/wjg.122311
Country China
Category Oncology
Manuscript Type Meta-Analysis
Article Title Modelling the impact of colorectal cancer screening strategies: A systematic review and meta-analysis
Manuscript Source Unsolicited Manuscript
All Author List Yi-Ke Yan, Yue-Lun Zhang, Bin Lu, Zhi-Liang He, Xin-Ran Cheng, Kai Song, Yu-Qing Chen, Jing-Jing Han, Hong-Da Chen and Min Dai
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 82273726
National Natural Science Foundation of China (General Program) 82473705
Beijing Research Ward Excellence Program BRWEP2024W034010101
Science and Technology Planning Project of Tibet Autonomous Region XZ202501JD0021
Capital’s Funds for Health Improvement and Research (CFH) 2026-2G-4026
PUMCH Talent Development and Support Program (Category B) UGG06641
National Key Research and Development Project of China 2024YFA0918501
Fundamental Research Funds for the Central Universities, Peking Union Medical College 3332025126
Corresponding Author Hong-Da Chen, Professor, Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. chenhongda@pumch.cn
Key Words Colorectal cancer; Screening; Effectiveness; Simulation modelling; Systematic review
Core Tip This meta-analysis of modeling studies shows that colorectal cancer screening substantially reduces incidence and mortality, with 10-yearly colonoscopy being most effective under perfect adherence. Emerging and hybrid strategies appear promising but with uncertain cost-effectiveness. Outcomes are strongly influenced by adherence and modelling assumptions, highlighting the need to balance effectiveness, real-world implementation, and economic considerations in screening policy decisions.
Citation Yan YK, Zhang YL, Lu B, He ZL, Cheng XR, Song K, Chen YQ, Han JJ, Chen HD, Dai M. Modelling the impact of colorectal cancer screening strategies: A systematic review and meta-analysis. World J Gastroenterol 2026; In press
PDF 122311-in-press.pdf
Received
2026-04-16 01:29
Peer-Review Started
2026-04-16 01:31
First Decision by Editorial Office Director
2026-04-30 07:23
Return for Revision
2026-04-30 07:23
Revised
2026-05-13 06:08
Publication Fee Transferred
2026-05-15 07:40
Second Decision by Editor
2026-06-26 02:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-26 06:16
Articles in Press
2026-06-26 06:16
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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