Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	122394
DOI	10.4240/wjgs.122394
Country	Türkiye

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Preoperative C-reactive protein and textbook outcome following pancreaticoduodenectomy for pancreatic head adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Ugur Topal, Burak Aydogan, Yunus Kaycı, Ishak Aydin, Mevlut Harun Agca, Serdar Gumus, Ahmet Gökhan Saritas, Abdullah Ulku and Atilgan Tolga Akcam
Funding Agency and Grant Number
Corresponding Author	Ugur Topal, Department of Surgical Oncology, Cukurova University, Balcalı Mahallesi, Sarıçam, Adana 01330, Türkiye. utopal@cu.edu.tr
Key Words	C-reactive protein; Pancreatic head adenocarcinoma; Pancreaticoduodenectomy; Postoperative complications; Risk stratification; Surgical quality; Textbook outcome
Core Tip	Textbook outcome (TO) provides a multidimensional benchmark for pancreaticoduodenectomy, but standardized TO data from Türkiye are scarce. In this single-center cohort of pancreaticoduodenectomy for pancreatic head adenocarcinoma, TO was achieved in 53.0% of patients. The main causes of TO failure were severe complications, readmission, and in-hospital mortality. Preoperative C-reactive protein remained the most consistent preoperative signal associated with TO achievement, and this association was not explained by biliary drainage or bilirubin. These findings position C-reactive protein as a practical marker for preoperative risk stratification rather than as a validated decision-making tool.
Citation	Topal U, Aydogan B, Kaycı Y, Aydin I, Agca MH, Gumus S, Saritas AG, Ulku A, Akcam AT. Preoperative C-reactive protein and textbook outcome following pancreaticoduodenectomy for pancreatic head adenocarcinoma. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.122394
PDF	122394-in-press.pdf

Received	2026-04-17 01:09
Peer-Review Started	2026-04-17 01:09
First Decision by Editorial Office Director	2026-04-27 08:53
Return for Revision	2026-04-27 08:53
Revised	2026-05-13 19:15
Publication Fee Transferred	2026-06-01 07:45
Second Decision by Editor	2026-06-16 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-16 06:26
Articles in Press	2026-06-16 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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