Publication Name	World Journal of Gastroenterology
Manuscript ID	122397
DOI	10.3748/wjg.122397
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Surgical safety and efficacy of neoadjuvant immunotherapy plus apatinib and chemotherapy in locally advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Wei Cheng, Meng Wei, Yuan Zhang, Yi-Ze Liang, Wei-Bo Cao, Ru-Dong Zhao, Zhi-Bo Yan, Guo-Rui Sun, Xiao-Han Cui and Wen-Bin Yu
Funding Agency and Grant Number	Funding Agency Grant Number Horizontal Project of Shandong University No. 6010123193, No. 6010121066, and No. 6010125120
Corresponding Author	Wen-Bin Yu, MD, PhD, Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. wenbin_yu2003@163.com
Key Words	Locally advanced gastric cancer; Immunotherapy; Apatinib; Neoadjuvant therapy; Surgery
Core Tip	This retrospective study of 292 patients with locally advanced gastric cancer demonstrated that programmed cell death protein-1 inhibitors plus apatinib and chemotherapy (PAC) significantly improved tumor regression response and survival outcomes compared with preoperative chemotherapy as a neoadjuvant therapy. The PAC regimen increased intraoperative blood loss, but did not compromise other surgical outcomes or postoperative recovery. Indocyanine green fluorescence guidance in the PAC group reduced the open conversion rate and enhanced lymph node yield. The PAC regimen was an independent prognostic predictor on multivariate analyses. Overall, PAC appears to be a promising neoadjuvant treatment option for locally advanced gastric cancer.
Citation	Cheng ZW, Wei M, Zhang Y, Liang YZ, Cao WB, Zhao RD, Yan ZB, Sun GR, Cui XH, Yu WB. Surgical safety and efficacy of neoadjuvant immunotherapy plus apatinib and chemotherapy in locally advanced gastric cancer. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122397
PDF	122397-in-press.pdf

Received	2026-04-17 09:58
Peer-Review Started	2026-04-17 09:59
First Decision by Editorial Office Director	2026-04-30 06:48
Return for Revision	2026-04-30 06:48
Revised	2026-05-10 14:38
Publication Fee Transferred	2026-05-13 03:29
Second Decision by Editor	2026-06-10 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-10 08:21
Articles in Press	2026-06-10 08:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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