Publication Name	World Journal of Psychiatry
Manuscript ID	122412
DOI	10.5498/wjp.122412
Country	China

Category	Psychology, Clinical
Manuscript Type	Retrospective Study
Article Title	Do serum biomarker levels correlate with anxiety disorders?
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Ping Li, Hai-Ling Ji, Shu-Yin Luo, Chun-Ying Zhu, Yu-Ting Qiu, Xin-Ling Zhang, Ya-Li Xu and Lei Jiang
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Health Information Association Research Program 2025XHZN-Z04
Corresponding Author	Ya-Li Xu, Hangzhou Tongchuang Medical Laboratory, Hangzhou Tongchuang Medical Laboratory, Hangzhou Tongchuang Medical Laboratory, Hangzhou 310022, Zhejiang Province, China. yali.xu@tclab.cn
Key Words	Anxiety disorder; Violence; Brain-derived neurotrophic factor; Aquaporin 4; Glycogen synthase kinase 3β; Mature brain-derived neurotrophic factor; Brain-derived neurotrophic factor precursor
Core Tip	This retrospective study investigated the role of serum biomarkers in distinguishing between healthy controls and patients with anxiety disorders and a history of violence. The case group exhibited reduced levels of serum brain-derived neurotrophic factor (BDNF), mature BDNF, and aquaporin-4, along with elevated levels of BDNF precursor and glycogen synthase kinase-3β. The combined diagnosis biomarker panel demonstrated significant discriminatory capacity (area under the curve = 0.9698). This combined diagnosis holds potential diagnostic value for identifying these patients with anxiety disorders.
Citation	Li XP, Ji HL, Luo SY, Zhu CY, Qiu YT, Zhang XL, Xu YL, Jiang L. Do serum biomarker levels correlate with anxiety disorders? World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.122412
PDF	122412-in-press.pdf

Received	2026-04-27 03:46
Peer-Review Started	2026-04-27 03:47
First Decision by Editorial Office Director	2026-05-15 10:54
Return for Revision	2026-05-15 10:54
Revised	2026-06-04 14:28
Publication Fee Transferred	2026-06-09 02:59
Second Decision by Editor	2026-06-26 02:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-26 05:49
Articles in Press	2026-06-26 05:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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