Publication Name	World Journal of Clinical Oncology
Manuscript ID	122421
DOI	10.5306/wjco.122421
Country	China

Category	Surgery
Manuscript Type	Case Control Study
Article Title	Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Wang, Yu-Lu He, Yin Gao, Xing-Rong Gao, Li-Yuan Sun, Ji-Cheng Yan, Qun Lu and Kai-Wen Ni
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 72504249
Corresponding Author	Kai-Wen Ni, PhD, Department of Infection Control, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, China. nkw721@zju.edu.cn
Key Words	Surgical site infection; Meningioma; Craniotomy; Risk factors; Perioperative assessment
Core Tip	This disease-specific case-control study is among the first to systematically evaluate preoperative host physiologic reserve indices - including the modified frailty index, nutritional risk index, neutrophil-to-lymphocyte ratio, and prognostic nutritional index - as predictors of surgical site infection following meningioma resection in a Chinese neurosurgical cohort. Using precisely measured operative time (skin incision to wound closure) and Least Absolute Shrinkage and Selection Operator-informed multivariable modeling, we identified a 3.04-hour operative threshold beyond which surgical site infection risk increases 5.7-fold, and established preoperative neutrophil-to-lymphocyte ratio as an independent immune-nutritional predictor. These findings provide clinically actionable criteria for prospective risk stratification and targeted perioperative optimization.
Citation	Wang H, He YL, Gao Y, Gao XR, Sun LY, Yan JC, Lu Q, Ni KW. Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.122421
PDF	122421-in-press.pdf

Received	2026-04-20 07:58
Peer-Review Started	2026-04-20 08:00
First Decision by Editorial Office Director
Return for Revision	2026-06-23 06:37
Revised	2026-06-30 00:52
Publication Fee Transferred	2026-07-07 09:07
Second Decision by Editor	2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:14
Articles in Press	2026-07-28 13:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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