Publication Name	World Journal of Gastroenterology
Manuscript ID	122438
DOI	10.3748/wjg.122438
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Microbiota-nutrition sequential therapy for refractory radiation proctitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Tao Huang, Yu-Long He, Guang Fu, Ling Chen, Shi-Tao Huang and Li-Ping Liu
Funding Agency and Grant Number	Funding Agency Grant Number Gansu Provincial Science and Technology Department 20JR5RA35 and 22JR10KA009 Lanzhou Chengguan District Science and Technology Bureau 2020RCCX0030 Gansu Natural Science Foundation 25JRRA567
Corresponding Author	Li-Ping Liu, MD, PhD, Professor, Department of Emergency Intensive Care Unit, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China. liulipingldyy@126.com
Key Words	Radiation proctitis; Fecal microbiota transplantation; Gut microbiome; Immunomodulatory enteral nutrition; Gut barrier function; Case report
Core Tip	This case demonstrates that combining fecal microbiota transplantation (FMT) with immunomodulatory enteral nutrition can achieve sustained clinical remission in refractory radiation proctitis after only two FMT courses, outperforming previous FMT-alone reports that required 4-7 sessions. The concurrent restoration of gut microbiota diversity, enrichment of beneficial genera (Faecalibacterium, Ruminococcus, Bacteroides), and downregulation of pro-inflammatory cytokines suggest a synergistic effect of nutritional support and microbial reconstruction in radiation-induced intestinal injury. These preliminary observations, however, warrant confirmation in larger prospective studies.
Citation	Huang T, He YL, Fu G, Chen L, Huang ST, Liu LP. Microbiota-nutrition sequential therapy for refractory radiation proctitis: A case report. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122438
PDF	122438-in-press.pdf

Received	2026-04-20 06:46
Peer-Review Started	2026-04-20 06:46
First Decision by Editorial Office Director
Return for Revision	2026-06-29 02:06
Revised	2026-07-11 15:22
Publication Fee Transferred	2026-07-22 03:12
Second Decision by Editor	2026-07-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:10
Articles in Press	2026-07-28 13:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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