Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	122448
DOI	10.4292/wjgpt.122448
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy
Manuscript Source	Invited Manuscript
All Author List	Keerthika Selvaraj and Chandrashekaran Girish
Funding Agency and Grant Number
Corresponding Author	Chandrashekaran Girish, Professor, Department of Pharmacology, Jawaharlal Institute of Post Graduate Medical Education and Research, JIPMER Campus Road, Gorimedu, Puducherry 605006, Dhanvantari Nagar, India. gcnx2005@gmail.com
Key Words	Antimicrobial peptide; Gut microbiota; Antimicrobial resistance; Immunomodulation; Intestinal barrier integrity; Inflammatory bowel disease; Nanotechnology-based delivery; Artificial intelligence in peptide design; Microbiome-targeted therapeutics
Core Tip	Antimicrobial peptides (AMPs) represent promising next-generation therapeutics that counter antimicrobial resistance through membrane disruption, immune modulation, and microbiome regulation. Their dual role in host defense and tissue homeostasis- particularly within gastrointestinal environments-underscores their broader physiological significance. Advances in artificial intelligence-driven peptide design and nanotechnology-based delivery systems are progressively addressing pharmacokinetic limitations and enhancing clinical viability. However, challenges including cytotoxicity, proteolytic instability, and high production costs remain. Integrating bioengineering, precision medicine, and microbiome-guided strategies holds considerable potential for establishing AMPs as personalized, clinically translatable anti-infective and immunomodulatory therapeutics.
Citation	Selvaraj K, Girish C. Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy. World J Gastrointest Pharmacol Ther 2026; In press DOI: https://doi.org/10.4292/wjgpt.122448
PDF	122448-in-press.pdf

Received	2026-04-23 06:22
Peer-Review Started	2026-04-23 06:22
First Decision by Editorial Office Director	2026-05-21 08:18
Return for Revision	2026-05-21 08:18
Revised	2026-06-25 04:58
Publication Fee Transferred
Second Decision by Editor	2026-07-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-28 13:07
Articles in Press	2026-07-28 13:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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