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Publication Name World Journal of Psychiatry
Manuscript ID 122462
Country China
Category Psychology, Clinical
Manuscript Type Prospective Study
Article Title Psychological distress in advanced non-small cell lung cancer: Impact on targeted therapy and quality of life
Manuscript Source Unsolicited Manuscript
All Author List Wen-Jun Chen, Xue-Yang Hu, Sen-Bang Yao, Mao-Xi Chen, Zi-Ran Bi and Huai-Dong Cheng
Funding Agency and Grant Number
Funding Agency Grant Number
the Shenzhen Science and Technology Program JCYJ20240813145301002, JCYJ20250604183455074
the National Natural Science Foundation of China 82573690
Corresponding Author Huai-Dong Cheng, MD, Professor, Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Avenue, Hefei 230000, Anhui Province, China. chd1975ay@126.com
Key Words Psychological distress; Targeted therapy; Quality of life; Non-small cell lung cancer; Prognosis
Core Tip This study is the first to demonstrate that psychological distress significantly impairs the efficacy of targeted therapy and quality of life in patients with advanced non-small cell lung cancer. Patients without distress showed superior objective response rates, disease control rates, and progression-free survival. Psychological distress is a critical factor affecting treatment outcomes, highlighting the need for routine distress screening and psychological support during non-small cell lung cancer targeted therapy.
Citation Chen WJ, Hu XY, Yao SB, Chen MX, Bi ZR, Cheng HD. Psychological distress in advanced non-small cell lung cancer: Impact on targeted therapy and quality of life. World J Psychiatry 2026; In press
Received
2026-04-30 09:23
Peer-Review Started
2026-04-30 09:23
First Decision by Editorial Office Director
2026-06-04 06:19
Return for Revision
2026-06-04 06:19
Revised
2026-06-17 16:12
Publication Fee Transferred
2026-06-25 13:12
Second Decision by Editor
2026-07-01 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-07-01 03:25
Articles in Press
2026-07-01 03:25
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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