Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	122497
DOI	10.4251/wjgo.122497
Country	China

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yun Wang, Yi-Wei Dong, Yang Wang, Yao-Yu Jin, Yu-Xuan Zhou and Yan Li
Funding Agency and Grant Number	Funding Agency Grant Number Jiaxing Peak Discipline - Oncology No. 2025-JF-003 Public Welfare Research Program of Jiaxing Municipal Bureau of Science and Technology No. 2024AD30031 The Project Supported by TCM Science and Technology Plan of Zhejiang Province, China No. 2023ZL699
Corresponding Author	Yan Li, Associate Chief Physician, Department of Gastrointestinal Surgery, The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), No. 1882 South Middle Ring Road, Jiaxing 314000, Zhejiang Province, China. liyan10647@163.com
Key Words	Advanced colorectal cancer; Gut microbial dysbiosis; Overall survival; Disease-free survival; Response to chemotherapy
Core Tip	This retrospective cohort study conducted a stratified analysis of patients with stage IIIB-IIIC and stage IV advanced colorectal cancer, confirming that gut microbiota dysbiosis – by modulating bile acid metabolism and the tumor immune microenvironment – is not only an independent adverse prognostic factor for overall survival but also significantly reduces the objective response rate to first-line chemotherapy.
Citation	Wang Y, Dong YW, Wang Y, Jin YY, Zhou YX, Li Y. Association between gut microbial dysbiosis and clinical prognosis of advanced colorectal cancer. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.122497
PDF	122497-in-press.pdf

Received	2026-05-15 09:58
Peer-Review Started	2026-05-15 09:58
First Decision by Editorial Office Director	2026-06-05 03:21
Return for Revision	2026-06-05 03:21
Revised	2026-06-16 02:54
Publication Fee Transferred	2026-06-22 03:23
Second Decision by Editor	2026-06-29 02:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-29 05:29
Articles in Press	2026-06-29 05:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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